Mitral annulus calcification is associated with valvular and cardiac structural abnormalities

Mohammad R Movahed, Yuji Saito, Mastaneh Ahmadi-Kashani, Ramin Ebrahimi

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Abstract

Introduction. Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. Methods. For this study we retrospectively reviewed 24,380 echocardiograms performed for clinical reasons between the years 1984 and 1998. Results. MAC was reported in 1,494 (6.1%) subjects. Using multivariate analysis, age, left ventricular hypertrophy (LVH), mitral regurgitation (MR), tricuspid regurgitation (TR), aortic stenosis (AS), left atrial (LA) enlargement and reversed E/A ratio were independently associated with MAC.)MAC was noted in 11.7 % of patients with MR vs. 4.3% without MR (OR: 2.0, CI 1.6-2.6, p < 0.0001), in 13.9% of those with TR vs. 4.5% without TR (OR: 3.8, CI 2.9-4.8, p < 0.0001), in 10.6% with LVH vs. 4.2% without LVH (OR: 1.9, CI 1.5-2.4, p < 0.0001), in 14.8% with AS vs. 5.5% without AS (OR: 1.4, CI 1.08-1.9, p = 0.01), in 9.4% with reversed E/A ratio vs. 3.8% without reversed E/A ratio (OR: 1.7, CI 1.4-2.2, p < 0.0001) and in 8.2% with LA enlargement vs. 4.8% without LA enlargement (OR: 1.3, CI 1.06-1.7, p = 0.02). Conclusion. In our study, MAC independently correlated with significant structural heart abnormalities. This suggests that identification of MAC may serve as a marker for other cardiac structural disorders.

Original languageEnglish (US)
Article number14
JournalCardiovascular Ultrasound
Volume5
DOIs
StatePublished - 2007

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Tricuspid Valve Insufficiency
Aortic Valve Stenosis
Mitral Valve Insufficiency
Left Ventricular Hypertrophy
Congenital Heart Defects
Multivariate Analysis
Databases

ASJC Scopus subject areas

  • Medicine(all)

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Mitral annulus calcification is associated with valvular and cardiac structural abnormalities. / Movahed, Mohammad R; Saito, Yuji; Ahmadi-Kashani, Mastaneh; Ebrahimi, Ramin.

In: Cardiovascular Ultrasound, Vol. 5, 14, 2007.

Research output: Contribution to journalArticle

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abstract = "Introduction. Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. Methods. For this study we retrospectively reviewed 24,380 echocardiograms performed for clinical reasons between the years 1984 and 1998. Results. MAC was reported in 1,494 (6.1{\%}) subjects. Using multivariate analysis, age, left ventricular hypertrophy (LVH), mitral regurgitation (MR), tricuspid regurgitation (TR), aortic stenosis (AS), left atrial (LA) enlargement and reversed E/A ratio were independently associated with MAC.)MAC was noted in 11.7 {\%} of patients with MR vs. 4.3{\%} without MR (OR: 2.0, CI 1.6-2.6, p < 0.0001), in 13.9{\%} of those with TR vs. 4.5{\%} without TR (OR: 3.8, CI 2.9-4.8, p < 0.0001), in 10.6{\%} with LVH vs. 4.2{\%} without LVH (OR: 1.9, CI 1.5-2.4, p < 0.0001), in 14.8{\%} with AS vs. 5.5{\%} without AS (OR: 1.4, CI 1.08-1.9, p = 0.01), in 9.4{\%} with reversed E/A ratio vs. 3.8{\%} without reversed E/A ratio (OR: 1.7, CI 1.4-2.2, p < 0.0001) and in 8.2{\%} with LA enlargement vs. 4.8{\%} without LA enlargement (OR: 1.3, CI 1.06-1.7, p = 0.02). Conclusion. In our study, MAC independently correlated with significant structural heart abnormalities. This suggests that identification of MAC may serve as a marker for other cardiac structural disorders.",
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N2 - Introduction. Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. Methods. For this study we retrospectively reviewed 24,380 echocardiograms performed for clinical reasons between the years 1984 and 1998. Results. MAC was reported in 1,494 (6.1%) subjects. Using multivariate analysis, age, left ventricular hypertrophy (LVH), mitral regurgitation (MR), tricuspid regurgitation (TR), aortic stenosis (AS), left atrial (LA) enlargement and reversed E/A ratio were independently associated with MAC.)MAC was noted in 11.7 % of patients with MR vs. 4.3% without MR (OR: 2.0, CI 1.6-2.6, p < 0.0001), in 13.9% of those with TR vs. 4.5% without TR (OR: 3.8, CI 2.9-4.8, p < 0.0001), in 10.6% with LVH vs. 4.2% without LVH (OR: 1.9, CI 1.5-2.4, p < 0.0001), in 14.8% with AS vs. 5.5% without AS (OR: 1.4, CI 1.08-1.9, p = 0.01), in 9.4% with reversed E/A ratio vs. 3.8% without reversed E/A ratio (OR: 1.7, CI 1.4-2.2, p < 0.0001) and in 8.2% with LA enlargement vs. 4.8% without LA enlargement (OR: 1.3, CI 1.06-1.7, p = 0.02). Conclusion. In our study, MAC independently correlated with significant structural heart abnormalities. This suggests that identification of MAC may serve as a marker for other cardiac structural disorders.

AB - Introduction. Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. Methods. For this study we retrospectively reviewed 24,380 echocardiograms performed for clinical reasons between the years 1984 and 1998. Results. MAC was reported in 1,494 (6.1%) subjects. Using multivariate analysis, age, left ventricular hypertrophy (LVH), mitral regurgitation (MR), tricuspid regurgitation (TR), aortic stenosis (AS), left atrial (LA) enlargement and reversed E/A ratio were independently associated with MAC.)MAC was noted in 11.7 % of patients with MR vs. 4.3% without MR (OR: 2.0, CI 1.6-2.6, p < 0.0001), in 13.9% of those with TR vs. 4.5% without TR (OR: 3.8, CI 2.9-4.8, p < 0.0001), in 10.6% with LVH vs. 4.2% without LVH (OR: 1.9, CI 1.5-2.4, p < 0.0001), in 14.8% with AS vs. 5.5% without AS (OR: 1.4, CI 1.08-1.9, p = 0.01), in 9.4% with reversed E/A ratio vs. 3.8% without reversed E/A ratio (OR: 1.7, CI 1.4-2.2, p < 0.0001) and in 8.2% with LA enlargement vs. 4.8% without LA enlargement (OR: 1.3, CI 1.06-1.7, p = 0.02). Conclusion. In our study, MAC independently correlated with significant structural heart abnormalities. This suggests that identification of MAC may serve as a marker for other cardiac structural disorders.

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