Fluid percussion injury (FPI) is capable of producing diffuse (midline FPI) and mixed (focal and diffuse; lateral FPI) injury pathologies that are frequently seen following human traumatic brain injury (TBI). The injuries produced with this model are scalable and can produce mild, moderate, and severe injury severities. The surgical procedures and assessment techniques described in this chapter are specific to adult rat and mouse models. However, this injury model can be used with subjects of any age and across different species. By following the procedures detailed in this chapter, it is possible to reproduce behavioral and pathophysiological characteristics of TBI in laboratory animals.
|Original language||English (US)|
|Title of host publication||Brain Neurotrauma|
|Subtitle of host publication||Molecular, Neuropsychological, and Rehabilitation Aspects|
|Number of pages||14|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas