Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data

Paloma Beamer, Kevin R. Plotkin, Charles P Gerba, Laura Y. Sifuentes, David W. Koenig, Kelly A Reynolds

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Although the number of illnesses resulting from indirect viral pathogen transmission could be substantial, it is difficult to estimate the relative risks because of the wide variation and uncertainty in human behavior, variable viral concentrations on fomites, and other exposure factors. The purpose of this study was to evaluate the micro-activity approach for assessment of microbial risk by adapting a mathematical model to estimate probability of viral infection from indirect transmission. To evaluate the model, measurements of phage loading on fomites and hands collected before and after implementation of a Healthy Workplace Project intervention were used. Parameter distributions were developed from these data, as well as for micro-activity rates, contact surface areas, phage transfer efficiencies, and inactivation rates. Following the Monte Carlo simulations (n = 1,000), the estimated phage loading on hands was not significantly different from the loading of phage on hands measured in the experimental trials. The model was then used to demonstrate that the Healthy Workplace Project intervention significantly reduced risk of infection by 77% for rotavirus and rhinovirus. This is the first published study to successfully evaluate a model focused on the indirect transmission of viruses via hand contact with measured data and provide an assessment of the micro-activity approach to microbial risk evaluation.

Original languageEnglish (US)
Pages (from-to)266-275
Number of pages10
JournalJournal of Occupational and Environmental Hygiene
Volume12
Issue number4
DOIs
StatePublished - Apr 3 2015

Fingerprint

Workplace
Bacteriophages
Fomites
Hand
Viruses
Infectious Disease Transmission
Infection
Rotavirus Infections
Rhinovirus
Virus Diseases
Uncertainty
Theoretical Models

Keywords

  • indirect pathogen transmission
  • infection risk
  • microactivity
  • office workers
  • viral infection
  • workplace intervention

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data. / Beamer, Paloma; Plotkin, Kevin R.; Gerba, Charles P; Sifuentes, Laura Y.; Koenig, David W.; Reynolds, Kelly A.

In: Journal of Occupational and Environmental Hygiene, Vol. 12, No. 4, 03.04.2015, p. 266-275.

Research output: Contribution to journalArticle

@article{e9fae5d7673a4dbd86d240e2b3c05fb7,
title = "Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data",
abstract = "Although the number of illnesses resulting from indirect viral pathogen transmission could be substantial, it is difficult to estimate the relative risks because of the wide variation and uncertainty in human behavior, variable viral concentrations on fomites, and other exposure factors. The purpose of this study was to evaluate the micro-activity approach for assessment of microbial risk by adapting a mathematical model to estimate probability of viral infection from indirect transmission. To evaluate the model, measurements of phage loading on fomites and hands collected before and after implementation of a Healthy Workplace Project intervention were used. Parameter distributions were developed from these data, as well as for micro-activity rates, contact surface areas, phage transfer efficiencies, and inactivation rates. Following the Monte Carlo simulations (n = 1,000), the estimated phage loading on hands was not significantly different from the loading of phage on hands measured in the experimental trials. The model was then used to demonstrate that the Healthy Workplace Project intervention significantly reduced risk of infection by 77{\%} for rotavirus and rhinovirus. This is the first published study to successfully evaluate a model focused on the indirect transmission of viruses via hand contact with measured data and provide an assessment of the micro-activity approach to microbial risk evaluation.",
keywords = "indirect pathogen transmission, infection risk, microactivity, office workers, viral infection, workplace intervention",
author = "Paloma Beamer and Plotkin, {Kevin R.} and Gerba, {Charles P} and Sifuentes, {Laura Y.} and Koenig, {David W.} and Reynolds, {Kelly A}",
year = "2015",
month = "4",
day = "3",
doi = "10.1080/15459624.2014.974808",
language = "English (US)",
volume = "12",
pages = "266--275",
journal = "Journal of Occupational and Environmental Hygiene",
issn = "1545-9624",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

TY - JOUR

T1 - Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data

AU - Beamer, Paloma

AU - Plotkin, Kevin R.

AU - Gerba, Charles P

AU - Sifuentes, Laura Y.

AU - Koenig, David W.

AU - Reynolds, Kelly A

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Although the number of illnesses resulting from indirect viral pathogen transmission could be substantial, it is difficult to estimate the relative risks because of the wide variation and uncertainty in human behavior, variable viral concentrations on fomites, and other exposure factors. The purpose of this study was to evaluate the micro-activity approach for assessment of microbial risk by adapting a mathematical model to estimate probability of viral infection from indirect transmission. To evaluate the model, measurements of phage loading on fomites and hands collected before and after implementation of a Healthy Workplace Project intervention were used. Parameter distributions were developed from these data, as well as for micro-activity rates, contact surface areas, phage transfer efficiencies, and inactivation rates. Following the Monte Carlo simulations (n = 1,000), the estimated phage loading on hands was not significantly different from the loading of phage on hands measured in the experimental trials. The model was then used to demonstrate that the Healthy Workplace Project intervention significantly reduced risk of infection by 77% for rotavirus and rhinovirus. This is the first published study to successfully evaluate a model focused on the indirect transmission of viruses via hand contact with measured data and provide an assessment of the micro-activity approach to microbial risk evaluation.

AB - Although the number of illnesses resulting from indirect viral pathogen transmission could be substantial, it is difficult to estimate the relative risks because of the wide variation and uncertainty in human behavior, variable viral concentrations on fomites, and other exposure factors. The purpose of this study was to evaluate the micro-activity approach for assessment of microbial risk by adapting a mathematical model to estimate probability of viral infection from indirect transmission. To evaluate the model, measurements of phage loading on fomites and hands collected before and after implementation of a Healthy Workplace Project intervention were used. Parameter distributions were developed from these data, as well as for micro-activity rates, contact surface areas, phage transfer efficiencies, and inactivation rates. Following the Monte Carlo simulations (n = 1,000), the estimated phage loading on hands was not significantly different from the loading of phage on hands measured in the experimental trials. The model was then used to demonstrate that the Healthy Workplace Project intervention significantly reduced risk of infection by 77% for rotavirus and rhinovirus. This is the first published study to successfully evaluate a model focused on the indirect transmission of viruses via hand contact with measured data and provide an assessment of the micro-activity approach to microbial risk evaluation.

KW - indirect pathogen transmission

KW - infection risk

KW - microactivity

KW - office workers

KW - viral infection

KW - workplace intervention

UR - http://www.scopus.com/inward/record.url?scp=84924931916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924931916&partnerID=8YFLogxK

U2 - 10.1080/15459624.2014.974808

DO - 10.1080/15459624.2014.974808

M3 - Article

VL - 12

SP - 266

EP - 275

JO - Journal of Occupational and Environmental Hygiene

JF - Journal of Occupational and Environmental Hygiene

SN - 1545-9624

IS - 4

ER -