Modeling systemic and renal gadolinium chelate transport with MRI

John R. Votaw, Diego R Martin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The advent of modern MRI scanners and computer equipment permits the rapid sequential collection of images of gadolinium chelate (Gd) transit through the kidney. The excellent spatial and temporal (0.9 s) resolution permits analyzing the shape of the recovered curves with a sophisticated model that includes both space and time. The purpose of this manuscript is to present such a mathematical model. By building into the model significant physical processes that contribute to the shape of the measured curve, quantitative values can be assigned to important parameters. In this work, quantitative values are determined for blood dispersion through the cardio-pulmonary system, systemic clearance rate of Gd, blood flow into each kidney, blood transit time in each kidney, the extraction rate of Gd across the capillary membrane, interstitial distribution volume, and the GFR for each kidney.

Original languageEnglish (US)
JournalPediatric Radiology
Volume38
Issue number1 SUPPL.
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Gadolinium
Kidney
Physical Phenomena
Theoretical Models
Equipment and Supplies
Lung
Membranes

Keywords

  • Children
  • Gadolinium
  • MRI
  • Renal function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health
  • Radiological and Ultrasound Technology

Cite this

Modeling systemic and renal gadolinium chelate transport with MRI. / Votaw, John R.; Martin, Diego R.

In: Pediatric Radiology, Vol. 38, No. 1 SUPPL., 01.2008.

Research output: Contribution to journalArticle

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