Abstract
Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382-3387, 2013.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3382-3387 |
| Number of pages | 6 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 101 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2013 |
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Keywords
- biomaterial
- modeling
- polycaprolactone
- polyester-urethane-urea
- statistic
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Ceramics and Composites
- Metals and Alloys
Cite this
Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s. / Warren, P. Daniel; Sycks, Dalton G.; Mcgrath, Dominic V; Vande Geest, Jonathan P.
In: Journal of Biomedical Materials Research - Part A, Vol. 101, No. 12, 12.2013, p. 3382-3387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s
AU - Warren, P. Daniel
AU - Sycks, Dalton G.
AU - Mcgrath, Dominic V
AU - Vande Geest, Jonathan P
PY - 2013/12
Y1 - 2013/12
N2 - Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382-3387, 2013.
AB - Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382-3387, 2013.
KW - biomaterial
KW - modeling
KW - polycaprolactone
KW - polyester-urethane-urea
KW - statistic
UR - http://www.scopus.com/inward/record.url?scp=84886725725&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886725725&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.34641
DO - 10.1002/jbm.a.34641
M3 - Article
C2 - 23554009
AN - SCOPUS:84886725725
VL - 101
SP - 3382
EP - 3387
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 0021-9304
IS - 12
ER -