Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s

P. Daniel Warren; Dalton G. Sycks; Dominic V. McGrath; Jonathan P. Vande Geest

doi:10.1002/jbm.a.34641

Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s

P. Daniel Warren, Dalton G. Sycks, Dominic V. McGrath, Jonathan P. Vande Geest

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R² = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382-3387, 2013.

Original language	English (US)
Pages (from-to)	3382-3387
Number of pages	6
Journal	Journal of Biomedical Materials Research - Part A
Volume	101
Issue number	12
DOIs	https://doi.org/10.1002/jbm.a.34641
State	Published - Dec 1 2013

Keywords

biomaterial
modeling
polycaprolactone
polyester-urethane-urea
statistic

ASJC Scopus subject areas

Ceramics and Composites
Biomaterials
Biomedical Engineering
Metals and Alloys

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title = "Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s",

abstract = "Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. {\textcopyright} 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382-3387, 2013.",

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author = "Warren, {P. Daniel} and Sycks, {Dalton G.} and McGrath, {Dominic V.} and {Vande Geest}, {Jonathan P.}",

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AU - Vande Geest, Jonathan P.

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