Modeling the sustained release of lipophilic drugs from liposomes

Like Zeng, Xiaoyi Wu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.

Original languageEnglish (US)
Article number073701
JournalApplied Physics Letters
Volume97
Issue number7
DOIs
StatePublished - Aug 16 2010

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drugs
lipids
compartments
delivery
convection
water
molecules
interactions

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Modeling the sustained release of lipophilic drugs from liposomes. / Zeng, Like; Wu, Xiaoyi.

In: Applied Physics Letters, Vol. 97, No. 7, 073701, 16.08.2010.

Research output: Contribution to journalArticle

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