Modeling the sustained release of lipophilic drugs from liposomes

Like Zeng, Xiaoyi Wu

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Abstract

The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.

Original languageEnglish (US)
Article number073701
JournalApplied Physics Letters
Volume97
Issue number7
DOIs
StatePublished - Aug 16 2010

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ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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