The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)