Modelling mammalian cellular quiescence

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-like' quiescent cells (e.g. fibroblasts, lymphocytes and stem cells) into proliferation is crucial for tissue repair and regeneration and a key to the growth, development and health of higher multicellular organisms, such as mammals. Quiescence has been a primarily phenotypic description (i.e. non-permanent cell cycle arrest) and poorly studied. However, contrary to the earlier thinking that quiescence is simply a passive and dormant state lacking proliferating activities, recent studies have revealed that cellular quiescence is actively maintained in the cell and that it corresponds to a collection of heterogeneous states. Recent modelling and experimental work have suggested that an Rb-E2F bistable switch plays a pivotal role in controlling the quiescence-proliferation balance and the heterogeneous quiescent states. Other quiescence regulatory activities may crosstalk with and impinge upon the Rb-E2F bistable switch, forming a gene network that controls the cells' quiescent states and their dynamic transitions to proliferation in response to noisy environmental signals. Elucidating the dynamic control mechanisms underlying quiescence may lead to novel therapeutic strategies that re-establish normal quiescent states, in a variety of hyperand hypo-proliferative diseases, including cancer and ageing.

Original languageEnglish (US)
JournalInterface Focus
Volume4
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Switches
Mammals
Lymphocytes
Cell proliferation
Fibroblasts
Crosstalk
Stem cells
Repair
Genes
Aging of materials
Gene Regulatory Networks
Cells
Health
Tissue
Cell Cycle Checkpoints
Growth and Development
Regeneration
Sleep
Stem Cells
Cell Proliferation

Keywords

  • Bistable switch
  • Cell cycle
  • Cellular quiescence
  • Gene network

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Biochemistry
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

Cite this

Modelling mammalian cellular quiescence. / Yao, Guang.

In: Interface Focus, Vol. 4, No. 3, 2014.

Research output: Contribution to journalArticle

@article{fb8e633e371340d3b7099931931f9edd,
title = "Modelling mammalian cellular quiescence",
abstract = "Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-like' quiescent cells (e.g. fibroblasts, lymphocytes and stem cells) into proliferation is crucial for tissue repair and regeneration and a key to the growth, development and health of higher multicellular organisms, such as mammals. Quiescence has been a primarily phenotypic description (i.e. non-permanent cell cycle arrest) and poorly studied. However, contrary to the earlier thinking that quiescence is simply a passive and dormant state lacking proliferating activities, recent studies have revealed that cellular quiescence is actively maintained in the cell and that it corresponds to a collection of heterogeneous states. Recent modelling and experimental work have suggested that an Rb-E2F bistable switch plays a pivotal role in controlling the quiescence-proliferation balance and the heterogeneous quiescent states. Other quiescence regulatory activities may crosstalk with and impinge upon the Rb-E2F bistable switch, forming a gene network that controls the cells' quiescent states and their dynamic transitions to proliferation in response to noisy environmental signals. Elucidating the dynamic control mechanisms underlying quiescence may lead to novel therapeutic strategies that re-establish normal quiescent states, in a variety of hyperand hypo-proliferative diseases, including cancer and ageing.",
keywords = "Bistable switch, Cell cycle, Cellular quiescence, Gene network",
author = "Guang Yao",
year = "2014",
doi = "10.1098/rsfs.2013.0074",
language = "English (US)",
volume = "4",
journal = "Interface Focus",
issn = "2042-8898",
publisher = "Royal Society Publishing",
number = "3",

}

TY - JOUR

T1 - Modelling mammalian cellular quiescence

AU - Yao, Guang

PY - 2014

Y1 - 2014

N2 - Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-like' quiescent cells (e.g. fibroblasts, lymphocytes and stem cells) into proliferation is crucial for tissue repair and regeneration and a key to the growth, development and health of higher multicellular organisms, such as mammals. Quiescence has been a primarily phenotypic description (i.e. non-permanent cell cycle arrest) and poorly studied. However, contrary to the earlier thinking that quiescence is simply a passive and dormant state lacking proliferating activities, recent studies have revealed that cellular quiescence is actively maintained in the cell and that it corresponds to a collection of heterogeneous states. Recent modelling and experimental work have suggested that an Rb-E2F bistable switch plays a pivotal role in controlling the quiescence-proliferation balance and the heterogeneous quiescent states. Other quiescence regulatory activities may crosstalk with and impinge upon the Rb-E2F bistable switch, forming a gene network that controls the cells' quiescent states and their dynamic transitions to proliferation in response to noisy environmental signals. Elucidating the dynamic control mechanisms underlying quiescence may lead to novel therapeutic strategies that re-establish normal quiescent states, in a variety of hyperand hypo-proliferative diseases, including cancer and ageing.

AB - Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-like' quiescent cells (e.g. fibroblasts, lymphocytes and stem cells) into proliferation is crucial for tissue repair and regeneration and a key to the growth, development and health of higher multicellular organisms, such as mammals. Quiescence has been a primarily phenotypic description (i.e. non-permanent cell cycle arrest) and poorly studied. However, contrary to the earlier thinking that quiescence is simply a passive and dormant state lacking proliferating activities, recent studies have revealed that cellular quiescence is actively maintained in the cell and that it corresponds to a collection of heterogeneous states. Recent modelling and experimental work have suggested that an Rb-E2F bistable switch plays a pivotal role in controlling the quiescence-proliferation balance and the heterogeneous quiescent states. Other quiescence regulatory activities may crosstalk with and impinge upon the Rb-E2F bistable switch, forming a gene network that controls the cells' quiescent states and their dynamic transitions to proliferation in response to noisy environmental signals. Elucidating the dynamic control mechanisms underlying quiescence may lead to novel therapeutic strategies that re-establish normal quiescent states, in a variety of hyperand hypo-proliferative diseases, including cancer and ageing.

KW - Bistable switch

KW - Cell cycle

KW - Cellular quiescence

KW - Gene network

UR - http://www.scopus.com/inward/record.url?scp=84899453151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899453151&partnerID=8YFLogxK

U2 - 10.1098/rsfs.2013.0074

DO - 10.1098/rsfs.2013.0074

M3 - Article

VL - 4

JO - Interface Focus

JF - Interface Focus

SN - 2042-8898

IS - 3

ER -