Models for navigating biological complexity in breeding improved crop plants

Graeme Hammer, Mark Cooper, François Tardieu, Stephen Welch, James "Bruce" Walsh, Fred van Eeuwijk, Scott Chapman, Dean Podlich

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

Progress in breeding higher-yielding crop plants would be greatly accelerated if the phenotypic consequences of making changes to the genetic makeup of an organism could be reliably predicted. Developing a predictive capacity that scales from genotype to phenotype is impeded by biological complexities associated with genetic controls, environmental effects and interactions among plant growth and development processes. Plant modelling can help navigate a path through this complexity. Here we profile modelling approaches for complex traits at gene network, organ and whole plant levels. Each provides a means to link phenotypic consequence to changes in genomic regions via stable associations with model coefficients. A unifying feature of the models is the relatively coarse level of granularity they use to capture system dynamics. Much of the fine detail is not directly required. Robust coarse-grained models might be the tool needed to integrate phenotypic and molecular approaches to plant breeding.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalTrends in Plant Science
Volume11
Issue number12
DOIs
StatePublished - Dec 2006

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Biological Models
Breeding
breeding
crops
Plant Development
Gene Regulatory Networks
Growth and Development
Genotype
Phenotype
plant breeding
plant development
growth and development
biological models
plant growth
genomics
phenotype
genotype
organisms

ASJC Scopus subject areas

  • Genetics

Cite this

Hammer, G., Cooper, M., Tardieu, F., Welch, S., Walsh, J. B., van Eeuwijk, F., ... Podlich, D. (2006). Models for navigating biological complexity in breeding improved crop plants. Trends in Plant Science, 11(12), 587-593. https://doi.org/10.1016/j.tplants.2006.10.006

Models for navigating biological complexity in breeding improved crop plants. / Hammer, Graeme; Cooper, Mark; Tardieu, François; Welch, Stephen; Walsh, James "Bruce"; van Eeuwijk, Fred; Chapman, Scott; Podlich, Dean.

In: Trends in Plant Science, Vol. 11, No. 12, 12.2006, p. 587-593.

Research output: Contribution to journalArticle

Hammer, G, Cooper, M, Tardieu, F, Welch, S, Walsh, JB, van Eeuwijk, F, Chapman, S & Podlich, D 2006, 'Models for navigating biological complexity in breeding improved crop plants', Trends in Plant Science, vol. 11, no. 12, pp. 587-593. https://doi.org/10.1016/j.tplants.2006.10.006
Hammer, Graeme ; Cooper, Mark ; Tardieu, François ; Welch, Stephen ; Walsh, James "Bruce" ; van Eeuwijk, Fred ; Chapman, Scott ; Podlich, Dean. / Models for navigating biological complexity in breeding improved crop plants. In: Trends in Plant Science. 2006 ; Vol. 11, No. 12. pp. 587-593.
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