Models of cognitive deficit and statistical hypotheses: Multiple sclerosis, an example

L. Ryan, C. M. Clark, H. Klonoff, D. Paty

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The purpose of the current study was to describe four models of cognitive deficit and to outline the statistical hypotheses underlying each model. The four models of cognitive deficit were (a) specific deficit; (b) subgroup deficit; (c) a syndrome dissociation model; and (d) a global function dissociation model. Neuropsychological data are analyzed to examine each of these four models in a sample of mild Multiple Sclerosis (MS) patients. The results suggest that for these subjects and tests, the specific deficit model best fits the data. The results are reviewed initially in the context of MS. There follows a consideration of statistical caveats and finally, general applications of the proposed procedures.

Original languageEnglish (US)
Pages (from-to)563-577
Number of pages15
JournalJournal of Clinical and Experimental Neuropsychology
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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