Multiple liposomal drugs have been successfully marketed as pharmaceuticals within the past two decades. Some of these clinically approved drugs, Doxil® in particular, have been shown to selectively localize within tumors due to the enhanced permeability and retention effect. However, a limitation exists with the inability to control content release once the drug gets to the desired location. Here we investigated the ability to apply a plasmon resonant coating to commercially available Doxil with the intention of spatially and temporally controlling doxorubicin release. While Doxil was successfully gold coated with a maximum plasmon resonant peak at 631 nm, the release at elevated temperature and on exposure to light was less than 10%. This result is similar to that observed for uncoated Doxil. Decreasing the pH had the same effect on both uncoated and plasmon resonant sample where a 10% increase in release was observed after samples were exposed to elevated temperature. Development of a highly efficient mechanism of light-activated drug release from Doxil will require a temperature-sensitive lipid composition.