Modification of commercial liposomal drug carrier by plasmon resonant coating

S. S. Knights-Mitchell, M. Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multiple liposomal drugs have been successfully marketed as pharmaceuticals within the past two decades. Some of these clinically approved drugs, Doxil® in particular, have been shown to selectively localize within tumors due to the enhanced permeability and retention effect. However, a limitation exists with the inability to control content release once the drug gets to the desired location. Here we investigated the ability to apply a plasmon resonant coating to commercially available Doxil with the intention of spatially and temporally controlling doxorubicin release. While Doxil was successfully gold coated with a maximum plasmon resonant peak at 631 nm, the release at elevated temperature and on exposure to light was less than 10%. This result is similar to that observed for uncoated Doxil. Decreasing the pH had the same effect on both uncoated and plasmon resonant sample where a 10% increase in release was observed after samples were exposed to elevated temperature. Development of a highly efficient mechanism of light-activated drug release from Doxil will require a temperature-sensitive lipid composition.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
PublisherNano Science and Technology Institute
Pages311-314
Number of pages4
ISBN (Print)9781482258271
StatePublished - Jan 1 2014
EventNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 - Washington, DC, United States
Duration: Jun 15 2014Jun 18 2014

Publication series

NameTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
Volume2

Other

OtherNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
CountryUnited States
CityWashington, DC
Period6/15/146/18/14

Keywords

  • Controlled release
  • Doxil
  • Doxorubicin
  • Liposomes
  • Plasmon resonance

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

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  • Cite this

    Knights-Mitchell, S. S., & Romanowski, M. (2014). Modification of commercial liposomal drug carrier by plasmon resonant coating. In Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 (pp. 311-314). (Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014; Vol. 2). Nano Science and Technology Institute.