Modification of resistance to Streptococcus pneumoniae by dietary ethanol, immunization, and murine retroviral infection

H. Darban, Ronald R Watson, J. R. Darban, L. M. Shahbazian

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hallmarks of the acquired immune deficiency syndrome (AIDS) are immunologic alterations, frequently associated with opportunistic infections. To study such associations, LP-BM5 murine retrovirus infection was used as a murine model of AIDS. Retrovirally infected and uninfected mice were fed a 5% (v/v) ethanol diet for 55 days and then fed a 7% v/v ethanol diet for the final 7 days to assert the role of ethanol as a cofactor in development of murine AIDS. There was a reduction in polymorphonuclear neutrophils count in ethanol-fed groups. Neutrophils increased in retrovirus-infected groups, except those vaccinated 10 days before challenge with live bacteria. The percentage of splenic lymphocytes in the retrovirus-infected group was reduced in comparison with controls. Survival of the mice challenged intraperitoneally with Streptococcus pneumoniae was increased by vaccination and suppressed by dietary alcohol. Retrovirus infection caused a much faster death rate after bacterial challenge than nonretrovirus infected controls. Vaccination played an important role in delaying the death rate in all treated groups. Transferring spleen cells from healthy, unimmunized mice also enabled the retrovirally infected mice to survive the bacterial infection longer. Enhancement of resistance to S. pneumoniae by vaccination and transfer of immunocompetent cells to mice immunosuppressed by retroviral infection show the potential to use immunomodulation to affect disease resistance in AIDS.

Original languageEnglish (US)
Pages (from-to)846-851
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number5
DOIs
StatePublished - 1992

Fingerprint

Immunization
Streptococcus pneumoniae
Ethanol
Murine Acquired Immunodeficiency Syndrome
Retroviridae Infections
Nutrition
Infection
Vaccination
Retroviridae
Acquired Immunodeficiency Syndrome
Neutrophils
Lymphocytes
Diet
Disease Resistance
Immunomodulation
Mortality
Opportunistic Infections
Bacteria
Bacterial Infections
Alcohols

Keywords

  • Adoptive Transfer
  • AIDS
  • Alcohol
  • Immunization
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Modification of resistance to Streptococcus pneumoniae by dietary ethanol, immunization, and murine retroviral infection. / Darban, H.; Watson, Ronald R; Darban, J. R.; Shahbazian, L. M.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 5, 1992, p. 846-851.

Research output: Contribution to journalArticle

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