Modification of thymic cell subsets induced by long-term cocaine administration during a murine retroviral infection producing AIDS

Maria C. Lopez, Lucas L. Colombo, Dennis S. Huang, Yuejian Wang, Ronald R Watson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

LP-BM5 murine leukemia virus (MuLV) infection and cocaine administration are known to impair the murine immune system. We have developed a murine model to study the effect of daily cocaine administration and retrovirus infection on the lymphoid cell populations of the thymus. C57BL/6 female mice were studied following chronic cocaine administration for 11 weeks with simultaneous LPBM5 MuLV infection. Cocaine administration reduced body and thymus weight, significantly reduced the number of CD8+ cells in the thymus, and partially prevented thymus enlargement due to lymphoid cell proliferation induced by LP-BM5 MuLV infection. Retrovirus infection was associated with a decrease in the percentage and absolute number of Thy 1.2+, CD4+, and CD8+ cells in the thymus, an effect potentiated by cocaine administration. Therefore cocaine impairs thymic function by altering the number of cells expressing T cell differentiation markers in MAIDS.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalClinical Immunology and Immunopathology
Volume65
Issue number1
DOIs
StatePublished - 1992

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Cocaine
Acquired Immunodeficiency Syndrome
Thymus Gland
Murine Leukemia Viruses
Virus Diseases
Infection
Retroviridae Infections
Murine Acquired Immunodeficiency Syndrome
Cell Count
Lymphocytes
Differentiation Antigens
Cell Differentiation
Immune System
Body Weight
Cell Proliferation
T-Lymphocytes
Population

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Modification of thymic cell subsets induced by long-term cocaine administration during a murine retroviral infection producing AIDS. / Lopez, Maria C.; Colombo, Lucas L.; Huang, Dennis S.; Wang, Yuejian; Watson, Ronald R.

In: Clinical Immunology and Immunopathology, Vol. 65, No. 1, 1992, p. 45-52.

Research output: Contribution to journalArticle

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