Modification of thymic cell subsets induced by long-term cocaine administration during a murine retroviral infection producing AIDS

Maria C. Lopez, Lucas L. Colombo, Dennis S. Huang, Yuejian Wang, Ronald R. Watson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

LP-BM5 murine leukemia virus (MuLV) infection and cocaine administration are known to impair the murine immune system. We have developed a murine model to study the effect of daily cocaine administration and retrovirus infection on the lymphoid cell populations of the thymus. C57BL/6 female mice were studied following chronic cocaine administration for 11 weeks with simultaneous LPBM5 MuLV infection. Cocaine administration reduced body and thymus weight, significantly reduced the number of CD8+ cells in the thymus, and partially prevented thymus enlargement due to lymphoid cell proliferation induced by LP-BM5 MuLV infection. Retrovirus infection was associated with a decrease in the percentage and absolute number of Thy 1.2+, CD4+, and CD8+ cells in the thymus, an effect potentiated by cocaine administration. Therefore cocaine impairs thymic function by altering the number of cells expressing T cell differentiation markers in MAIDS.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalClinical Immunology and Immunopathology
Volume65
Issue number1
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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