The effects of GABA on the binding of analogues of benzodiazepine, triazolopyridazines, β-carbolines and imidazodiazepines were examined in ligand/[3H]flunitrazepan competition experiments. GABA increased the potency of anxiolytics, like flunitrazepam, whereas the potency of benzodiazepine antagonists, like Ro15-1788, was largely insensitive to the influence of GABA. Several other agents including pyrazolopyridines, barbiturates and etomidate caused a chloride dependent enhancement of [3H]flunitrazepam binding but not an enhancement of [3H]propyl-β-carboline-3-carboxylate binding.
- Benzodiazepine receptor agonists and antagonists
ASJC Scopus subject areas