Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS)

M. Araghi-Niknam, B. Liang, Z. Zhang, S. K. Ardestani, Ronald R Watson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Ageing, leukaemia and acquired immune deficiency syndrome (AIDS) are conditions with dysregulated cytokine production. As dehydroepiandrosterone sulphate (DHEAS) restored normal cytokine production in old mice its effects on retrovirally infected old mice were investigated. Retrovirus infection and ageing-induced immune dysfunction. Murine retrovirus-infected old C57BL/6 female mice-consumed 0.22 or 0.44 μg of DHEAS/mouse/day beginning 2 weeks postinfection for 10 weeks. DHEAS largely prevented the retrovirus-induced reduction in T-cell and B-cell mitogenesis. DHEAS supplement prevented loss of cytokines [interleukin-2 (IL-2) and interferon-γ secretion by mitogen-stimulated splenocytes representing T helper 1 (Th1) cell phenotypes. It also suppressed the retrovirus-induced, excessive production of cytokines (IL-6 and IL-10) by Th2 cells. The highest dose of DHEAS reduced IL-6 production by splenocytes from uninfected old mice by 75% while increasing their IL-2 secretion by nearly 50%. Thus immune dysfunction induced by ageing, even when exacerbated by murine retrovirus infection, was largely prevented by DHEAS.

Original languageEnglish (US)
Pages (from-to)344-349
Number of pages6
JournalImmunology
Volume90
Issue number3
StatePublished - 1997

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Retroviridae Infections
Dehydroepiandrosterone Sulfate
Leukemia
Retroviridae
Cytokines
Interleukin-2
Interleukin-6
Th2 Cells
Th1 Cells
Mitogens
Interleukin-10
Interferons
Acquired Immunodeficiency Syndrome
B-Lymphocytes
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS). / Araghi-Niknam, M.; Liang, B.; Zhang, Z.; Ardestani, S. K.; Watson, Ronald R.

In: Immunology, Vol. 90, No. 3, 1997, p. 344-349.

Research output: Contribution to journalArticle

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