Modulation of phencyclidine (PCP) pharmacokinetics with PCP-specific fab fragments

S. M. Owens, Michael Mayersohn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A promising technique for detoxification of certain drugs is the use of drug-specific antibody fragments (Fab, the antigen-binding fragment of IgG). This type of treatment has been shown to reverse digoxin and digitoxin toxicity rapidly in both animals and humans. The purpose of this paper is to discuss the important factors in the use of immunotherapy for treating PCP toxicity and to present preliminary data on the effects of anti-PCP Fab fragments on PCP pharmacokinetics in dogs.

Original languageEnglish (US)
Pages (from-to)112-126
Number of pages15
JournalNIDA research monograph
VolumeNO. 64
StatePublished - 1986
Externally publishedYes

Fingerprint

Phencyclidine
Immunoglobulin Fab Fragments
Pharmacokinetics
Digitoxin
Immunoglobulin Fragments
Digoxin
Pharmaceutical Preparations
Immunotherapy
Immunoglobulin G
Dogs
Antigens
Therapeutics

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Modulation of phencyclidine (PCP) pharmacokinetics with PCP-specific fab fragments. / Owens, S. M.; Mayersohn, Michael.

In: NIDA research monograph, Vol. NO. 64, 1986, p. 112-126.

Research output: Contribution to journalArticle

@article{c56d5a62fd75455989a2ceae97a74ec3,
title = "Modulation of phencyclidine (PCP) pharmacokinetics with PCP-specific fab fragments",
abstract = "A promising technique for detoxification of certain drugs is the use of drug-specific antibody fragments (Fab, the antigen-binding fragment of IgG). This type of treatment has been shown to reverse digoxin and digitoxin toxicity rapidly in both animals and humans. The purpose of this paper is to discuss the important factors in the use of immunotherapy for treating PCP toxicity and to present preliminary data on the effects of anti-PCP Fab fragments on PCP pharmacokinetics in dogs.",
author = "Owens, {S. M.} and Michael Mayersohn",
year = "1986",
language = "English (US)",
volume = "NO. 64",
pages = "112--126",
journal = "NIDA Research Monograph Series",
issn = "1046-9516",
publisher = "National Institute on Drug Abuse",

}

TY - JOUR

T1 - Modulation of phencyclidine (PCP) pharmacokinetics with PCP-specific fab fragments

AU - Owens, S. M.

AU - Mayersohn, Michael

PY - 1986

Y1 - 1986

N2 - A promising technique for detoxification of certain drugs is the use of drug-specific antibody fragments (Fab, the antigen-binding fragment of IgG). This type of treatment has been shown to reverse digoxin and digitoxin toxicity rapidly in both animals and humans. The purpose of this paper is to discuss the important factors in the use of immunotherapy for treating PCP toxicity and to present preliminary data on the effects of anti-PCP Fab fragments on PCP pharmacokinetics in dogs.

AB - A promising technique for detoxification of certain drugs is the use of drug-specific antibody fragments (Fab, the antigen-binding fragment of IgG). This type of treatment has been shown to reverse digoxin and digitoxin toxicity rapidly in both animals and humans. The purpose of this paper is to discuss the important factors in the use of immunotherapy for treating PCP toxicity and to present preliminary data on the effects of anti-PCP Fab fragments on PCP pharmacokinetics in dogs.

UR - http://www.scopus.com/inward/record.url?scp=0022931478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022931478&partnerID=8YFLogxK

M3 - Article

C2 - 3086729

AN - SCOPUS:0022931478

VL - NO. 64

SP - 112

EP - 126

JO - NIDA Research Monograph Series

JF - NIDA Research Monograph Series

SN - 1046-9516

ER -