Modulation of the Immune Response of Guinea Pigs by Repeated BCG Scarification

Leona C. Peters; M. G. Hanna; Jordan V. Gutterman; G. M. Mavligit; Evan M. Hersh

doi:10.3181/00379727-147-38338

Modulation of the Immune Response of Guinea Pigs by Repeated BCG Scarification

Leona C. Peters, M. G. Hanna, Jordan V. Gutterman, G. M. Mavligit, Evan M. Hersh

Cancer Center

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Abstract

Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random-bred CFDH as well as inbred (syngeneic) strain-2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.

Original language	English (US)
Pages (from-to)	344-349
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	147
Issue number	2
DOIs	https://doi.org/10.3181/00379727-147-38338
State	Published - Nov 1974

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Modulation of the Immune Response of Guinea Pigs by Repeated BCG Scarification",

abstract = "Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random-bred CFDH as well as inbred (syngeneic) strain-2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.",

author = "Peters, {Leona C.} and Hanna, {M. G.} and Gutterman, {Jordan V.} and Mavligit, {G. M.} and Hersh, {Evan M.}",

note = "Funding Information: Research in part supported jointly by the Carcinogenesis Program of the National Cancer Institute and the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation. 11 1974 147 2 344 349 ",

year = "1974",

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doi = "10.3181/00379727-147-38338",

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T1 - Modulation of the Immune Response of Guinea Pigs by Repeated BCG Scarification

AU - Peters, Leona C.

AU - Hanna, M. G.

AU - Gutterman, Jordan V.

AU - Mavligit, G. M.

AU - Hersh, Evan M.

N1 - Funding Information: Research in part supported jointly by the Carcinogenesis Program of the National Cancer Institute and the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation. 11 1974 147 2 344 349

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N2 - Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random-bred CFDH as well as inbred (syngeneic) strain-2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.

AB - Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random-bred CFDH as well as inbred (syngeneic) strain-2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.

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Modulation of the Immune Response of Guinea Pigs by Repeated BCG Scarification

Abstract

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