Abstract
Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random bred Carworth Duncan Hartly as well as inbred (syngeneic) strain 2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 344-349 |
| Number of pages | 6 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 147 |
| Issue number | 2 |
| State | Published - 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Modulation of the immune response of guinea pigs by repeated BCG scarification. / Peters, L. C.; Hanna, M. G.; Gutterman, J. V.; Mavligit, G. M.; Hersh, Evan M.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 147, No. 2, 1974, p. 344-349.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of the immune response of guinea pigs by repeated BCG scarification
AU - Peters, L. C.
AU - Hanna, M. G.
AU - Gutterman, J. V.
AU - Mavligit, G. M.
AU - Hersh, Evan M
PY - 1974
Y1 - 1974
N2 - Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random bred Carworth Duncan Hartly as well as inbred (syngeneic) strain 2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.
AB - Immune competence to sheep erythrocytes, skin allografts, and antigenic tumor transplants was studied in random bred Carworth Duncan Hartly as well as inbred (syngeneic) strain 2 guinea pigs receiving repeated BCG scarification. Peripheral blood leucocyte (PBL) changes and histopathological alterations of the skin site and regional lymph nodes were also evaluated during the course of treatment. The results demonstrate that in this experimental model BCG scarification depresses humoral immune competence and augments cellular immunity. Elevation of the PBL counts was also indicative of an acute systemic effect resulting from repeated BCG treatment. Flaring of previous scarification sites, activation and enlargement of draining nodes, and progressive responsiveness of nodes draining sites of previous scarification were also observed.
UR - http://www.scopus.com/inward/record.url?scp=0016328201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016328201&partnerID=8YFLogxK
M3 - Article
C2 - 4612551
AN - SCOPUS:0016328201
VL - 147
SP - 344
EP - 349
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 0037-9727
IS - 2
ER -