Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level

Maha Zewail-Foote, Laurence Hurley

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In this article we first very briefly review current approaches to the design of drugs that have specificity for the modulation of gene expression and selectivity for target cells at the transcription level by targeting DNA. We focus this review on our approaches to gaining selectivity by drug-induced architectural alteration in DNA structure, selectivity achieved by protein-induced changes in DNA structure or dynamics, and hijacking of nuclear receptors.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAnti-Cancer Drug Design
Volume14
Issue number1
StatePublished - Feb 1999
Externally publishedYes

Fingerprint

Gene expression
Gene Expression
DNA
Pharmaceutical Preparations
Drug Design
Transcription
Cytoplasmic and Nuclear Receptors
Modulation
Proteins

Keywords

  • Antitumour drugs
  • DNA bending
  • Protein-DNA complexes
  • Transcriptional control

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level. / Zewail-Foote, Maha; Hurley, Laurence.

In: Anti-Cancer Drug Design, Vol. 14, No. 1, 02.1999, p. 1-9.

Research output: Contribution to journalArticle

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