Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level

Maha Zewail-Foote, Laurence H. Hurley

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

In this article we first very briefly review current approaches to the design of drugs that have specificity for the modulation of gene expression and selectivity for target cells at the transcription level by targeting DNA. We focus this review on our approaches to gaining selectivity by drug-induced architectural alteration in DNA structure, selectivity achieved by protein-induced changes in DNA structure or dynamics, and hijacking of nuclear receptors.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAnti-Cancer Drug Design
Volume14
Issue number1
StatePublished - Feb 1999

Keywords

  • Antitumour drugs
  • DNA bending
  • Protein-DNA complexes
  • Transcriptional control

ASJC Scopus subject areas

  • Biochemistry
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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