Molecular archeological evidence in support of the repeated loss of a papillomavirus gene

Koenraad Van Doorslaer, Alison A. McBride

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

It is becoming clear that, in addition to gene gain, the loss of genes may be an important evolutionary mechanism for many organisms. However, gene loss is often associated with an increased mutation rate, thus quickly erasing evidence from the genome. The analysis of evolutionarily related sequences can provide empirical evidence for gene loss events. This paper analyzes the sequences of over 300 genetically distinct papillomaviruses and provides evidence for a role of gene loss during the evolution of certain papillomavirus genomes. Phylogenetic analysis suggests that the viral E6 gene was lost at least twice. Despite belonging to distant papillomaviral genera, these viruses lacking a canonical E6 protein may potentially encode a highly hydrophobic protein from an overlapping open reading frame, which we designate E10. Evolutionary pressure working on this alternative frame, may explain why, despite having lost the E6 open reading frame between 20 and 60 million years ago, evidence of an E6-like protein is conserved.

Original languageEnglish (US)
Article number33028
JournalScientific reports
Volume6
DOIs
StatePublished - Sep 8 2016
Externally publishedYes

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Genes
Open Reading Frames
Genome
Proteins
Viral Genes
Mutation Rate
Sequence Analysis
Viruses
Pressure

ASJC Scopus subject areas

  • General

Cite this

Molecular archeological evidence in support of the repeated loss of a papillomavirus gene. / Van Doorslaer, Koenraad; McBride, Alison A.

In: Scientific reports, Vol. 6, 33028, 08.09.2016.

Research output: Contribution to journalArticle

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