Molecular cloning of the murine PHEX gene promoter1

Eric R. Hines, James F. Collins, Fayez K. Ghishan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We report the novel cloning of the murine PHEX promoter, the gene that is mutated in X-linked hypophosphatemic rickets (XLH). Four promoter/reporter gene constructs, -133/+104, -542/+104, -1061/+104, and -2866/+104, showed significant luciferase activity (4.9-13.2-fold over background) when transfected into rat osteogenic sarcoma (UMR-106) cells.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1493
Issue number3
DOIs
StatePublished - Oct 2 2000

Keywords

  • Hyp mouse
  • PEX
  • UMR-106 cells
  • X-linked rickets

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Molecular cloning of the murine PHEX gene promoter<sup>1</sup>'. Together they form a unique fingerprint.

Cite this