Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas

Burt G. Feuerstein, Gayatry Mohapatra

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The unregulated growth that is characteristic of human malignant gliomas is accompanied by, and may result from, losses and/or gains of genetic material. Understanding the mechanisms that underlie how particular genetic aberrations cause dysfunctional growth will help elucidate the pathogenesis of this disease. Two techniques are proving useful in evaluating the clinical relevance of specific genetic aberrations in malignant gliomas. Fluorescence in situ hybridization (FISH) permits direct visualization of gains and losses of genetic material in single cells and quantitation of cellular subpopulations that have particular genetic aberrations. Comparative genomic hybridization can identify regions of genetic gain and loss in tumor DNA.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalJournal of Neuro-Oncology
Volume24
Issue number1
DOIs
StatePublished - Feb 1995

Keywords

  • amplification
  • comparative genomic hybridization
  • deletion
  • fluorescence in situ hybridization
  • heterogeneity
  • malignant glioma
  • tumor genetics

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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