Molecular determinants and the regulation of human cytomegalovirus latency and reactivation

Donna Collins-McMillen, Jason Buehler, Megan Peppenelli, Felicia Goodrum

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes are maintained in a quieted state. Virus replication can be reactivated from latency in response to changes in cellular signaling caused by stress or differentiation. The past decade has brought great insights into the molecular basis of HCMV latency. Here, we review the complex persistence of HCMV with consideration of latent reservoirs, viral determinants and their host interactions, and host signaling and the control of cellular and viral gene expression that contributes to the establishment of and reactivation from latency.

Original languageEnglish (US)
Article number444
JournalViruses
Volume10
Issue number8
DOIs
StatePublished - Aug 20 2018

Keywords

  • Epigenetic regulation
  • Human cytomegalovirus
  • Latency
  • Reactivation
  • Signaling
  • Transcription factors

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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