Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome.

L. M. Silver, Michael F Hammer, H. Fox, J. Garrels, M. Bucan, B. Herrmann, A. M. Frischauf, H. Lehrach, H. Winking, F. Figueroa

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Mouse t haplotypes are variant forms of chromosome 17 that exist at high frequencies in worldwide populations of two species of commensal mice. To determine both the relationship of t haplotypes to each other and the species within which they exist, 35 representative t haplotypes were analyzed by means of 10 independent molecular probes, including five DNA clones and five polypeptide spots identified by means of two-dimensional gel electrophoresis. All of the tested haplotypes were found to share restriction fragments and polypeptide spots that are absent in mice carrying wild-type forms of chromosome 17. This observation provides the first direct evidence that all of the known t haplotypes are descendents of a single ancestral chromosome. The absence of variation among t haplotypes could mean that this ancestral chromosome existed relatively recently, in which case it would be necessary to postulate introgressions of t haplotypes across species lines to explain their presence in both Mus domesticus and M. musculus. Alternatively, it is possible that the ancestral chromosome existed prior to the split between M. domesticus and M. musculus and that, by chance, our probes fail to detect polymorphisms that exist among the t haplotypes. A further result of our analysis is the characterization of a partial t haplotype in a wild population of Israeli mice.

Original languageEnglish (US)
Pages (from-to)473-482
Number of pages10
JournalMolecular Biology and Evolution
Volume4
Issue number5
StatePublished - Sep 1987
Externally publishedYes

Fingerprint

t-Complex Genome Region
Chromosomes
Haplotypes
chromosome
haplotypes
chromosomes
mice
Chromosomes, Human, Pair 17
probe
Molecular Probes
Peptides
commensal
introgression
wild population
Electrophoresis
Polymorphism
polypeptides
clone
electrokinesis
polymorphism

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

Cite this

Silver, L. M., Hammer, M. F., Fox, H., Garrels, J., Bucan, M., Herrmann, B., ... Figueroa, F. (1987). Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. Molecular Biology and Evolution, 4(5), 473-482.

Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. / Silver, L. M.; Hammer, Michael F; Fox, H.; Garrels, J.; Bucan, M.; Herrmann, B.; Frischauf, A. M.; Lehrach, H.; Winking, H.; Figueroa, F.

In: Molecular Biology and Evolution, Vol. 4, No. 5, 09.1987, p. 473-482.

Research output: Contribution to journalArticle

Silver, LM, Hammer, MF, Fox, H, Garrels, J, Bucan, M, Herrmann, B, Frischauf, AM, Lehrach, H, Winking, H & Figueroa, F 1987, 'Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome.', Molecular Biology and Evolution, vol. 4, no. 5, pp. 473-482.
Silver, L. M. ; Hammer, Michael F ; Fox, H. ; Garrels, J. ; Bucan, M. ; Herrmann, B. ; Frischauf, A. M. ; Lehrach, H. ; Winking, H. ; Figueroa, F. / Molecular evidence for the rapid propagation of mouse t haplotypes from a single, recent, ancestral chromosome. In: Molecular Biology and Evolution. 1987 ; Vol. 4, No. 5. pp. 473-482.
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