Molecular genetics of corticosteroid action

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The recent isolation and characterization of steroid receptor coding sequences has revolutionized the field of steroid hormone action. These studies have revealed that steroid receptors are members of a much larger nuclear receptor 'super family'. The ligand and DNA binding domains have been shown to be molecular components that functionally interact to transform the steroid-receptor complex into a highly specific gene regulator that induces or represses the expression of cell-specific target genes. Molecular genetic approaches have been used to study structure-function relationships of several steroid receptor proteins, the most extensive analysis has been that of the glucocorticoid receptor. Several breakthroughs in the study of steroid hormone action include the construction of novel chimeric steroid receptor proteins, functional expression of steroid receptors in yeast, and the development of sensitive cloning techniques designed to isolate low abundance, hormonally regulated transcripts.

Original languageEnglish (US)
JournalAmerican Review of Respiratory Disease
Volume141
Issue number2 II SUPPL.
StatePublished - 1990

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Steroid Receptors
Molecular Biology
Adrenal Cortex Hormones
Steroids
Hormones
Glucocorticoid Receptors
Regulator Genes
Cytoplasmic and Nuclear Receptors
Organism Cloning
Proteins
Yeasts
Ligands
DNA
Genes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Molecular genetics of corticosteroid action. / Miesfeld, Roger.

In: American Review of Respiratory Disease, Vol. 141, No. 2 II SUPPL., 1990.

Research output: Contribution to journalArticle

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