Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development

Lars R Furenlid, Harrison H Barrett, H. Bradford Barber, Eric W Clarkson, Matthew A Kupinski, Zhonglin Liu, Gail D. Stevenson, James M. Woolfenden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

During the past two decades, researchers at the University of Arizona's Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSPIE
Volume9186
ISBN (Print)9781628412130
DOIs
StatePublished - 2014
Event50 Years of Optical Sciences at the University of Arizona - San Diego, United States
Duration: Aug 19 2014Aug 20 2014

Other

Other50 Years of Optical Sciences at the University of Arizona
CountryUnited States
CitySan Diego
Period8/19/148/20/14

Fingerprint

Molecular imaging
Gamma Rays
Instrumentation
Gamma rays
tomography
Imaging
Computed Tomography
gamma rays
Photon
Solid State Detectors
Camera
Cameras
cameras
Single photon emission computed tomography
Detectors
Imaging techniques
X-ray Tomography
Positron Emission Tomography
Optical gain
Synthetic apertures

Keywords

  • collimation
  • CT
  • detectors
  • estimation
  • instrumentation
  • molecular imaging
  • PET
  • reconstruction
  • SPECT

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Furenlid, L. R., Barrett, H. H., Barber, H. B., Clarkson, E. W., Kupinski, M. A., Liu, Z., ... Woolfenden, J. M. (2014). Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 9186). [91860J] SPIE. https://doi.org/10.1117/12.2064808

Molecular imaging in the College of Optical Sciences : An overview of two decades of instrumentation development. / Furenlid, Lars R; Barrett, Harrison H; Barber, H. Bradford; Clarkson, Eric W; Kupinski, Matthew A; Liu, Zhonglin; Stevenson, Gail D.; Woolfenden, James M.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9186 SPIE, 2014. 91860J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Furenlid, LR, Barrett, HH, Barber, HB, Clarkson, EW, Kupinski, MA, Liu, Z, Stevenson, GD & Woolfenden, JM 2014, Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 9186, 91860J, SPIE, 50 Years of Optical Sciences at the University of Arizona, San Diego, United States, 8/19/14. https://doi.org/10.1117/12.2064808
Furenlid, Lars R ; Barrett, Harrison H ; Barber, H. Bradford ; Clarkson, Eric W ; Kupinski, Matthew A ; Liu, Zhonglin ; Stevenson, Gail D. ; Woolfenden, James M. / Molecular imaging in the College of Optical Sciences : An overview of two decades of instrumentation development. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9186 SPIE, 2014.
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