Molecular imaging in the College of Optical Sciences: An overview of two decades of instrumentation development

Lars R. Furenlid, Harrison H. Barrett, H. Bradford Barber, Eric W. Clarkson, Matthew A. Kupinski, Zhonglin Liu, Gail D. Stevenson, James M. Woolfenden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

During the past two decades, researchers at the University of Arizona's Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.

Original languageEnglish (US)
Title of host publicationFifty Years of Optical Sciences at the University of Arizona
EditorsJohn E. Greivenkamp, Eustace L. Dereniak, Harrison H. Barrett
PublisherSPIE
ISBN (Electronic)9781628412130
DOIs
StatePublished - 2014
Event50 Years of Optical Sciences at the University of Arizona - San Diego, United States
Duration: Aug 19 2014Aug 20 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9186
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

Other50 Years of Optical Sciences at the University of Arizona
CountryUnited States
CitySan Diego
Period8/19/148/20/14

Keywords

  • CT
  • PET
  • SPECT
  • collimation
  • detectors
  • estimation
  • instrumentation
  • molecular imaging
  • reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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