Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics

Xianchun Li, Mary A. Schuler, May R. Berenbaum

Research output: Contribution to journalArticle

880 Citations (Scopus)

Abstract

Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.

Original languageEnglish (US)
Pages (from-to)231-253
Number of pages23
JournalAnnual Review of Entomology
Volume52
DOIs
StatePublished - 2007

Fingerprint

xenobiotics
insecticide
allelochemical
gene
insecticide resistance
allelochemicals
genomics
insecticides
genes
metabolism
detoxification
glutathione transferase
cytochrome P-450
esterases
transposons
cytochrome
mutation
amplification
nucleotides
insect

Keywords

  • Allelochemical
  • Cytochrome P450
  • Esterase
  • Evolution
  • Glutathione-S- transferase
  • Insecticide

ASJC Scopus subject areas

  • Insect Science

Cite this

Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics. / Li, Xianchun; Schuler, Mary A.; Berenbaum, May R.

In: Annual Review of Entomology, Vol. 52, 2007, p. 231-253.

Research output: Contribution to journalArticle

@article{caca9c909ed547c0a6a2bfe87eff18fa,
title = "Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics",
abstract = "Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.",
keywords = "Allelochemical, Cytochrome P450, Esterase, Evolution, Glutathione-S- transferase, Insecticide",
author = "Xianchun Li and Schuler, {Mary A.} and Berenbaum, {May R.}",
year = "2007",
doi = "10.1146/annurev.ento.51.110104.151104",
language = "English (US)",
volume = "52",
pages = "231--253",
journal = "Annual Review of Entomology",
issn = "0066-4170",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics

AU - Li, Xianchun

AU - Schuler, Mary A.

AU - Berenbaum, May R.

PY - 2007

Y1 - 2007

N2 - Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.

AB - Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.

KW - Allelochemical

KW - Cytochrome P450

KW - Esterase

KW - Evolution

KW - Glutathione-S- transferase

KW - Insecticide

UR - http://www.scopus.com/inward/record.url?scp=33846401539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846401539&partnerID=8YFLogxK

U2 - 10.1146/annurev.ento.51.110104.151104

DO - 10.1146/annurev.ento.51.110104.151104

M3 - Article

C2 - 16925478

AN - SCOPUS:33846401539

VL - 52

SP - 231

EP - 253

JO - Annual Review of Entomology

JF - Annual Review of Entomology

SN - 0066-4170

ER -