Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning

AustinT Hilliard, Julie Elizabeth Miller, Elizabeth R. Fraley, Steve Horvath, StephanieA White

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Similarities between speech and birdsong make songbirds advantageous for investigating the neurogenetics of learned vocal communication-a complex phenotype probably supported by ensembles of interacting genes in cortico-basal ganglia pathways of both species. To date, only FoxP2 has been identified as critical to both speech and birdsong. We performed weighted gene coexpression network analysis on microarray data from singing zebra finches to discover gene ensembles regulated during vocal behavior. We found ∼2,000 singing-regulated genes comprising three coexpression groups unique to area X, the basal ganglia subregion dedicated to learned vocalizations. These contained known targets of human FOXP2 and potential avian targets. We validated biological pathways not previously implicated in vocalization. Higher-order gene coexpression patterns, rather than expression levels, molecularly distinguish area X from the ventral striato-pallidum during singing. The previously unknown structure of singing-driven networks enables prioritization of molecular interactors that probably bear on human motor disorders, especially those affecting speech.

Original languageEnglish (US)
Pages (from-to)537-552
Number of pages16
JournalNeuron
Volume73
Issue number3
DOIs
StatePublished - Feb 9 2012
Externally publishedYes

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Singing
Basal Ganglia
Learning
Genes
Finches
Songbirds
Gene Order
Equidae
Gene Regulatory Networks
Microarray Analysis
Communication
Phenotype

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning. / Hilliard, AustinT; Miller, Julie Elizabeth; Fraley, Elizabeth R.; Horvath, Steve; White, StephanieA.

In: Neuron, Vol. 73, No. 3, 09.02.2012, p. 537-552.

Research output: Contribution to journalArticle

Hilliard, AustinT ; Miller, Julie Elizabeth ; Fraley, Elizabeth R. ; Horvath, Steve ; White, StephanieA. / Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning. In: Neuron. 2012 ; Vol. 73, No. 3. pp. 537-552.
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