Molecular pharmacology of muscarinic receptor heterogeneity

Lin Mei, William R Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarinic receptor types and G proteins may depend on the systems in which the receptors are integrated. Expression of the cloned gene in mammalian cells will be useful in delineating the relationships between the pharmacological types of muscarinic receptors and their genes and studying the interactions between the receptor, G proteins, and second messenger coupling.

Original languageEnglish (US)
Pages (from-to)1831-1851
Number of pages21
JournalLife Sciences
Volume45
Issue number20
DOIs
StatePublished - 1989

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Muscarinic Receptors
Pharmacology
Genes
Second Messenger Systems
GTP-Binding Proteins
Cells
Gene Expression

ASJC Scopus subject areas

  • Pharmacology

Cite this

Molecular pharmacology of muscarinic receptor heterogeneity. / Mei, Lin; Roeske, William R; Yamamura, Henry I.

In: Life Sciences, Vol. 45, No. 20, 1989, p. 1831-1851.

Research output: Contribution to journalArticle

Mei, Lin ; Roeske, William R ; Yamamura, Henry I. / Molecular pharmacology of muscarinic receptor heterogeneity. In: Life Sciences. 1989 ; Vol. 45, No. 20. pp. 1831-1851.
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