Molecular Physiology of Gastrointestinal Function During Development

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The mammalian intestinal tract undergoes dramatic changes during the first few weeks of postnatal life. Genetic and neurohormonal regulators influence the changes in digestive and transport functions that mediate the development of the gut. In mammals, the most significant changes occur during the suckling/weaning transition. At birth, the digestive and secretory function of intestines is not fully developed, and thus nutrient absorption occurs throughout the small and large intestines and along the entire length of the crypt-villus axis. During the suckling period, factors from the mother's milk affect intestinal function and regulate the expression of genes involved in nutrient transport and immune function. After weaning, a different set of physiologic regulators and dietary factors direct rapid functional maturation of the gut epithelium. This chapter reviews the key discoveries that have led to the current understanding of ontogenic maturation of the gastrointestinal function (secretory, digestive, absorptive, and ontogenic regulation).

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Pages235-269
Number of pages35
Volume1-2
ISBN (Electronic)9780128124260
ISBN (Print)9780128099544
DOIs
StatePublished - Mar 28 2018

Fingerprint

Weaning
Food
Large Intestine
Small Intestine
Intestines
Mammals
Milk
Epithelium
Parturition
Gene Expression

Keywords

  • Digestion
  • Intestinal maturation
  • Secretion
  • Water/salt/ions/vitamins/bile absorption and ontogenic regulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Xu, H., & Ghishan, F. K. (2018). Molecular Physiology of Gastrointestinal Function During Development. In Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 235-269). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809954-4.00010-4

Molecular Physiology of Gastrointestinal Function During Development. / Xu, Hua; Ghishan, Fayez K.

Physiology of the Gastrointestinal Tract: Sixth Edition. Vol. 1-2 Elsevier Inc., 2018. p. 235-269.

Research output: Chapter in Book/Report/Conference proceedingChapter

Xu, H & Ghishan, FK 2018, Molecular Physiology of Gastrointestinal Function During Development. in Physiology of the Gastrointestinal Tract: Sixth Edition. vol. 1-2, Elsevier Inc., pp. 235-269. https://doi.org/10.1016/B978-0-12-809954-4.00010-4
Xu H, Ghishan FK. Molecular Physiology of Gastrointestinal Function During Development. In Physiology of the Gastrointestinal Tract: Sixth Edition. Vol. 1-2. Elsevier Inc. 2018. p. 235-269 https://doi.org/10.1016/B978-0-12-809954-4.00010-4
Xu, Hua ; Ghishan, Fayez K. / Molecular Physiology of Gastrointestinal Function During Development. Physiology of the Gastrointestinal Tract: Sixth Edition. Vol. 1-2 Elsevier Inc., 2018. pp. 235-269
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