Molecular Regulation of Cardiac Chamber-Specific Gene Expression

Eric M. Small, Paul A. Krieg

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume14
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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