Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum

J. M. Bjorneby, B. D. Hunsaker, Michael W Riggs, L. E. Perryman

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Three groups of congenitally athymic nude mice were persistently infected following oral administration of 2 x 107 Cryptosporidium parvum oocysts. Two groups were treated once daily for 10 days with either neutralizing monoclonal antibody (MAb) 17.41 or an isotype control MAb. The third group received no treatment. Intestinal-infection scores were significantly decreased in nude mice treated with MAb 17.41 compared with isotype control MAb-treated and nontreated control groups (P < 0.005). biliary and pancreatic crytosporidial-infection cores were similar for the MAb 17.41-treated and isotype control MAb-treated groups (P > 0.05).

Original languageEnglish (US)
Pages (from-to)1172-1176
Number of pages5
JournalInfection and Immunity
Volume59
Issue number3
StatePublished - 1991
Externally publishedYes

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Cryptosporidium parvum
Nude Mice
Immunotherapy
Monoclonal Antibodies
Oocysts
Neutralizing Antibodies
Oral Administration
Control Groups
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum. / Bjorneby, J. M.; Hunsaker, B. D.; Riggs, Michael W; Perryman, L. E.

In: Infection and Immunity, Vol. 59, No. 3, 1991, p. 1172-1176.

Research output: Contribution to journalArticle

Bjorneby, J. M. ; Hunsaker, B. D. ; Riggs, Michael W ; Perryman, L. E. / Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum. In: Infection and Immunity. 1991 ; Vol. 59, No. 3. pp. 1172-1176.
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