Monoclonal antibody immunotherapy in nude mice persistently infected with CRyptosporidium parvum

J. M. Bjorneby, B. D. Hunsaker, M. W. Riggs, L. E. Perryman

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Three groups of congenitally athymic nude mice were persistently infected following oral administration of 2 x 107 Cryptosporidium parvum oocysts. Two groups were treated once daily for 10 days with either neutralizing monoclonal antibody (MAb) 17.41 or an isotype control MAb. The third group received no treatment. Intestinal-infection scores were significantly decreased in nude mice treated with MAb 17.41 compared with isotype control MAb-treated and nontreated control groups (P < 0.005). biliary and pancreatic crytosporidial-infection cores were similar for the MAb 17.41-treated and isotype control MAb-treated groups (P > 0.05).

Original languageEnglish (US)
Pages (from-to)1172-1176
Number of pages5
JournalInfection and Immunity
Volume59
Issue number3
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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