Montagnuphilones a-g, azaphilones from Montagnulaceae sp. DM0194, a fungal endophyte of submerged roots of Persicaria amphibia

Jian Guang Luo, Ya Ming Xu, Dustin C. Sandberg, A. Elizabeth Arnold, A. A Leslie Gunatilaka

Research output: Research - peer-reviewArticle

Abstract

Seven azaphilones, montagnuphilones A.G (1.7), together with previously known azaphilones 8.11, were encountered in Montagnulaceae sp. DM0194, an endophytic fungus isolated from submerged roots of Persicaria amphibia. The structures of 1.7 were elucidated on the basis of their MS and NMR spectroscopic analysis. Compounds 1.8 were evaluated for their cytotoxicity and ability to inhibit nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophage cells. Among these, none were found to be cytotoxic to RAW264.7 cells up to 100.0 μM, but 8, 5, and 2 showed NO inhibitory activity with IC50 values of 9.2 ± 0.9, 25.5 ± 1.1, and 39.6 ± 1.8 μM, respectively.

LanguageEnglish (US)
Pages76-81
Number of pages6
JournalJournal of Natural Products
Volume80
Issue number1
DOIs
StatePublished - Jan 27 2017

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Endophytes
Amphibians
Nitric Oxide
azaphilone
Lipopolysaccharides
Fungi
Macrophages
Spectroscopic analysis
Cytotoxicity
Nuclear magnetic resonance

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Montagnuphilones a-g, azaphilones from Montagnulaceae sp. DM0194, a fungal endophyte of submerged roots of Persicaria amphibia. / Luo, Jian Guang; Xu, Ya Ming; Sandberg, Dustin C.; Arnold, A. Elizabeth; Gunatilaka, A. A Leslie.

In: Journal of Natural Products, Vol. 80, No. 1, 27.01.2017, p. 76-81.

Research output: Research - peer-reviewArticle

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