Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

Edita Navratilova, Miriam C. Eaton, Dagmar Stropova, Eva V. Varga, Todd W Vanderah, William R Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

After prolonged stimulation, the δ-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human δ-opioid receptor. Morphine-mediated phosphorylation reached 53 ± 8% of maximum deltorphin II-mediated phosphorylation. Phosphorylation of S363 may contribute to δ-opioid receptor desensitization by morphine.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalEuropean Journal of Pharmacology
Volume519
Issue number3
DOIs
StatePublished - Sep 20 2005

Fingerprint

Opioid Receptors
Serine
Morphine
Phosphorylation
Down-Regulation

Keywords

  • δ-opioid receptor
  • Morphine
  • Receptor phosphorylation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363. / Navratilova, Edita; Eaton, Miriam C.; Stropova, Dagmar; Varga, Eva V.; Vanderah, Todd W; Roeske, William R; Yamamura, Henry I.

In: European Journal of Pharmacology, Vol. 519, No. 3, 20.09.2005, p. 212-214.

Research output: Contribution to journalArticle

Navratilova, Edita ; Eaton, Miriam C. ; Stropova, Dagmar ; Varga, Eva V. ; Vanderah, Todd W ; Roeske, William R ; Yamamura, Henry I. / Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363. In: European Journal of Pharmacology. 2005 ; Vol. 519, No. 3. pp. 212-214.
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AU - Vanderah, Todd W

AU - Roeske, William R

AU - Yamamura, Henry I.

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