Morphologic and biochemical effects of intratracheally administered oil shale in rats.

R. A. Renne, L. G. Smith, K. E. McDonald, C. A. Shields, A Jay Gandolfi, J. E. Lund

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Young adult rats were given three weekly intratracheal instillations of 30 mg of raw oil shale or spent oil shale suspended in 1.0 ml sterile physiological saline. Positive control groups received similar instillations of 30 mg or 5 mg of quartz. Animals were sacrificed and tissue samples taken for histopathology and biochemical analyses at 3 weeks, 7 weeks, 4 months, and 8 months following the first instillation. Rats exposed to raw shale, spent shale or quartz had increased lung weights compared with controls. Microscopically, all exposed groups developed granulomatous pneumonia and alveolar lipoproteinosis; pulmonary fibrosis was most severe in the quartz-exposed groups and progressed with time in these groups. Total amounts of pulmonary hydroxyproline, prolyl hydroxylase, total protein, and lipid phosphate were increased in shale or quartz-exposed groups; however, concentration of these substances on a per gram of lung tissue basis was not different from control groups.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalJournal of Environmental Pathology and Toxicology
Volume3
Issue number5-6
StatePublished - Jun 1980
Externally publishedYes

Fingerprint

Quartz
Oil shale
Rats
Oils
Shale
Lung
Lipoid Proteinosis of Urbach and Wiethe
Hydroxyproline
Tissue
Prolyl Hydroxylases
Control Groups
Pulmonary Fibrosis
Young Adult
Pneumonia
Animals
Phosphates
Lipids
Weights and Measures
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Renne, R. A., Smith, L. G., McDonald, K. E., Shields, C. A., Gandolfi, A. J., & Lund, J. E. (1980). Morphologic and biochemical effects of intratracheally administered oil shale in rats. Journal of Environmental Pathology and Toxicology, 3(5-6), 397-406.

Morphologic and biochemical effects of intratracheally administered oil shale in rats. / Renne, R. A.; Smith, L. G.; McDonald, K. E.; Shields, C. A.; Gandolfi, A Jay; Lund, J. E.

In: Journal of Environmental Pathology and Toxicology, Vol. 3, No. 5-6, 06.1980, p. 397-406.

Research output: Contribution to journalArticle

Renne, RA, Smith, LG, McDonald, KE, Shields, CA, Gandolfi, AJ & Lund, JE 1980, 'Morphologic and biochemical effects of intratracheally administered oil shale in rats.', Journal of Environmental Pathology and Toxicology, vol. 3, no. 5-6, pp. 397-406.
Renne, R. A. ; Smith, L. G. ; McDonald, K. E. ; Shields, C. A. ; Gandolfi, A Jay ; Lund, J. E. / Morphologic and biochemical effects of intratracheally administered oil shale in rats. In: Journal of Environmental Pathology and Toxicology. 1980 ; Vol. 3, No. 5-6. pp. 397-406.
@article{f6fe6641444a41b8b36190a20a197c98,
title = "Morphologic and biochemical effects of intratracheally administered oil shale in rats.",
abstract = "Young adult rats were given three weekly intratracheal instillations of 30 mg of raw oil shale or spent oil shale suspended in 1.0 ml sterile physiological saline. Positive control groups received similar instillations of 30 mg or 5 mg of quartz. Animals were sacrificed and tissue samples taken for histopathology and biochemical analyses at 3 weeks, 7 weeks, 4 months, and 8 months following the first instillation. Rats exposed to raw shale, spent shale or quartz had increased lung weights compared with controls. Microscopically, all exposed groups developed granulomatous pneumonia and alveolar lipoproteinosis; pulmonary fibrosis was most severe in the quartz-exposed groups and progressed with time in these groups. Total amounts of pulmonary hydroxyproline, prolyl hydroxylase, total protein, and lipid phosphate were increased in shale or quartz-exposed groups; however, concentration of these substances on a per gram of lung tissue basis was not different from control groups.",
author = "Renne, {R. A.} and Smith, {L. G.} and McDonald, {K. E.} and Shields, {C. A.} and Gandolfi, {A Jay} and Lund, {J. E.}",
year = "1980",
month = "6",
language = "English (US)",
volume = "3",
pages = "397--406",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
issn = "0731-8898",
publisher = "Begell House Inc.",
number = "5-6",

}

TY - JOUR

T1 - Morphologic and biochemical effects of intratracheally administered oil shale in rats.

AU - Renne, R. A.

AU - Smith, L. G.

AU - McDonald, K. E.

AU - Shields, C. A.

AU - Gandolfi, A Jay

AU - Lund, J. E.

PY - 1980/6

Y1 - 1980/6

N2 - Young adult rats were given three weekly intratracheal instillations of 30 mg of raw oil shale or spent oil shale suspended in 1.0 ml sterile physiological saline. Positive control groups received similar instillations of 30 mg or 5 mg of quartz. Animals were sacrificed and tissue samples taken for histopathology and biochemical analyses at 3 weeks, 7 weeks, 4 months, and 8 months following the first instillation. Rats exposed to raw shale, spent shale or quartz had increased lung weights compared with controls. Microscopically, all exposed groups developed granulomatous pneumonia and alveolar lipoproteinosis; pulmonary fibrosis was most severe in the quartz-exposed groups and progressed with time in these groups. Total amounts of pulmonary hydroxyproline, prolyl hydroxylase, total protein, and lipid phosphate were increased in shale or quartz-exposed groups; however, concentration of these substances on a per gram of lung tissue basis was not different from control groups.

AB - Young adult rats were given three weekly intratracheal instillations of 30 mg of raw oil shale or spent oil shale suspended in 1.0 ml sterile physiological saline. Positive control groups received similar instillations of 30 mg or 5 mg of quartz. Animals were sacrificed and tissue samples taken for histopathology and biochemical analyses at 3 weeks, 7 weeks, 4 months, and 8 months following the first instillation. Rats exposed to raw shale, spent shale or quartz had increased lung weights compared with controls. Microscopically, all exposed groups developed granulomatous pneumonia and alveolar lipoproteinosis; pulmonary fibrosis was most severe in the quartz-exposed groups and progressed with time in these groups. Total amounts of pulmonary hydroxyproline, prolyl hydroxylase, total protein, and lipid phosphate were increased in shale or quartz-exposed groups; however, concentration of these substances on a per gram of lung tissue basis was not different from control groups.

UR - http://www.scopus.com/inward/record.url?scp=0019030782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019030782&partnerID=8YFLogxK

M3 - Article

C2 - 7441092

AN - SCOPUS:0019030782

VL - 3

SP - 397

EP - 406

JO - Journal of Environmental Pathology, Toxicology and Oncology

JF - Journal of Environmental Pathology, Toxicology and Oncology

SN - 0731-8898

IS - 5-6

ER -