Morphological development of the brain stem reticular core in prenatally undernourished rats

Ronald P Hammer, Edith van Marthens

Research output: Contribution to journalArticle

Abstract

The development of brain stem reticular core neurons in prenatally undernourished rats was investigated using the Golgi technique to determine the effect of immediate postnatal nutritional rehabilitation. Quantitative measurements of dendritic extent of branching and of cell size were compared in experimental and control neurons. An assessment of developmental dendritic status was achieved by counting numbers of dendritic protospines and varicosities on proximal and distal segments of dendrite. The protein and DNA content of the brain stem was also examined. The deficit of brain stem cell number at birth was rapidly restored by 11 days of age as was the delay of dendritic development. The number of dendritic protospines was comparable to control levels by 20 days but dendritic varicosities were more numerous on proximal segments. The dendritic extent increased during this period with rehabilitation though not as greatly as in control cells. The pattern of dendritic branching and size of somata were restored. Cell replication with rehabilitation probably represents a return of glial numbers which may impede distal dendritic growth of reticular core dendrites. Proximal growth is enhanced and the afferent supply to the reticular core may be increased during this time.

Original languageEnglish (US)
Pages (from-to)203-212
Number of pages10
JournalDevelopmental Brain Research
Volume1
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Brain Stem
Rehabilitation
Dendrites
Neurons
Carisoprodol
Growth
Cell Size
Neuroglia
Stem Cells
Cell Count
Parturition
DNA
Proteins

Keywords

  • dendrites
  • dendritic development
  • nutritional rehabilitation
  • reticular core
  • undernutrition

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Morphological development of the brain stem reticular core in prenatally undernourished rats. / Hammer, Ronald P; van Marthens, Edith.

In: Developmental Brain Research, Vol. 1, No. 2, 1981, p. 203-212.

Research output: Contribution to journalArticle

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