Mortality associated with short sleep duration: The evidence, the possible mechanisms, and the future

Michael A. Grandner, Lauren Hale, Melisa Moore, Nirav P. Patel

Research output: Contribution to journalReview articlepeer-review

300 Scopus citations

Abstract

This review of the scientific literature examines the widely observed relationship between sleep duration and mortality. As early as 1964, data have shown that 7-h sleepers experience the lowest risks for all-cause mortality, whereas those at the shortest and longest sleep durations have significantly higher mortality risks. Numerous follow-up studies from around the world (e.g., Japan, Israel, Sweden, Finland, the United Kingdom) show similar relationships. We discuss possible mechanisms, including cardiovascular disease, obesity, physiologic stress, immunity, and socioeconomic status. We put forth a social-ecological framework to explore five possible pathways for the relationship between sleep duration and mortality, and we conclude with a four-point agenda for future research.

Original languageEnglish (US)
Pages (from-to)191-203
Number of pages13
JournalSleep Medicine Reviews
Volume14
Issue number3
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • Epidemiology
  • Health
  • Mortality
  • Sleep duration

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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