Mortality estimates among adult patients with severe acute respiratory infections from two sentinel hospitals in southern Arizona, United States, 2010-2014

Steve R. Barnes, Zimy Wansaula, Kristen Herrick, Eyal - Oren, Kacey C Ernst, Sonja J. Olsen, Mariana G. Casal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: From October 2010 through February 2016, Arizona conducted surveillance for severe acute respiratory infections (SARI) among adults hospitalized in the Arizona-Mexico border region. There are few accurate mortality estimates in SARI patients, particularly in adults ≥ 65 years old. The purpose of this study was to generate mortality estimates among SARI patients that include deaths occurring shortly after hospital discharge and identify risk factors for mortality. Methods: Patients admitted to two sentinel hospitals between 2010 and 2014 who met the SARI case definition were enrolled. Demographic data were used to link SARI patients to Arizona death certificates. Mortality within 30 days after the date of admission was calculated and risk factors were identified using logistic regression models. Results: Among 258 SARI patients, 47% were females, 51% were white, non-Hispanic and 39% were Hispanic. The median age was 63 years (range, 19 to 97 years) and 80% had one or more pre-existing health condition; 9% died in hospital. Mortality increased to 12% (30/258, 30% increase) when electronic vital records and a 30-day post-hospitalization time frame were used. Being age ≥ 65 years (OR = 4.0; 95% CI: 1.6-9.9) and having an intensive care unit admission (OR = 7.4; 95% CI: 3.0-17.9) were independently associated with mortality. Conclusion: The use of electronic vital records increased SARI-associated mortality estimates by 30%. These findings may help guide prevention and treatment measures, particularly in high-risk persons in this highly fluid border population.

Original languageEnglish (US)
Article number78
JournalBMC Infectious Diseases
Volume18
Issue number1
DOIs
StatePublished - Feb 12 2018

Fingerprint

Respiratory Tract Infections
Mortality
Logistic Models
Preexisting Condition Coverage
Death Certificates
Mexico
cyhalothrin
Hispanic Americans
Intensive Care Units
Hospitalization
Demography
Health
Population

Keywords

  • Arizona
  • Death certificates
  • Fatal outcome
  • Influenza
  • Respiratory tract diseases
  • Surveillance

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Mortality estimates among adult patients with severe acute respiratory infections from two sentinel hospitals in southern Arizona, United States, 2010-2014. / Barnes, Steve R.; Wansaula, Zimy; Herrick, Kristen; Oren, Eyal -; Ernst, Kacey C; Olsen, Sonja J.; Casal, Mariana G.

In: BMC Infectious Diseases, Vol. 18, No. 1, 78, 12.02.2018.

Research output: Contribution to journalArticle

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abstract = "Background: From October 2010 through February 2016, Arizona conducted surveillance for severe acute respiratory infections (SARI) among adults hospitalized in the Arizona-Mexico border region. There are few accurate mortality estimates in SARI patients, particularly in adults ≥ 65 years old. The purpose of this study was to generate mortality estimates among SARI patients that include deaths occurring shortly after hospital discharge and identify risk factors for mortality. Methods: Patients admitted to two sentinel hospitals between 2010 and 2014 who met the SARI case definition were enrolled. Demographic data were used to link SARI patients to Arizona death certificates. Mortality within 30 days after the date of admission was calculated and risk factors were identified using logistic regression models. Results: Among 258 SARI patients, 47{\%} were females, 51{\%} were white, non-Hispanic and 39{\%} were Hispanic. The median age was 63 years (range, 19 to 97 years) and 80{\%} had one or more pre-existing health condition; 9{\%} died in hospital. Mortality increased to 12{\%} (30/258, 30{\%} increase) when electronic vital records and a 30-day post-hospitalization time frame were used. Being age ≥ 65 years (OR = 4.0; 95{\%} CI: 1.6-9.9) and having an intensive care unit admission (OR = 7.4; 95{\%} CI: 3.0-17.9) were independently associated with mortality. Conclusion: The use of electronic vital records increased SARI-associated mortality estimates by 30{\%}. These findings may help guide prevention and treatment measures, particularly in high-risk persons in this highly fluid border population.",
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AU - Herrick, Kristen

AU - Oren, Eyal -

AU - Ernst, Kacey C

AU - Olsen, Sonja J.

AU - Casal, Mariana G.

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AB - Background: From October 2010 through February 2016, Arizona conducted surveillance for severe acute respiratory infections (SARI) among adults hospitalized in the Arizona-Mexico border region. There are few accurate mortality estimates in SARI patients, particularly in adults ≥ 65 years old. The purpose of this study was to generate mortality estimates among SARI patients that include deaths occurring shortly after hospital discharge and identify risk factors for mortality. Methods: Patients admitted to two sentinel hospitals between 2010 and 2014 who met the SARI case definition were enrolled. Demographic data were used to link SARI patients to Arizona death certificates. Mortality within 30 days after the date of admission was calculated and risk factors were identified using logistic regression models. Results: Among 258 SARI patients, 47% were females, 51% were white, non-Hispanic and 39% were Hispanic. The median age was 63 years (range, 19 to 97 years) and 80% had one or more pre-existing health condition; 9% died in hospital. Mortality increased to 12% (30/258, 30% increase) when electronic vital records and a 30-day post-hospitalization time frame were used. Being age ≥ 65 years (OR = 4.0; 95% CI: 1.6-9.9) and having an intensive care unit admission (OR = 7.4; 95% CI: 3.0-17.9) were independently associated with mortality. Conclusion: The use of electronic vital records increased SARI-associated mortality estimates by 30%. These findings may help guide prevention and treatment measures, particularly in high-risk persons in this highly fluid border population.

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