Motilin acts within the CNS to inhibit urinary bladder contractions

Frank Porreca, Andre Dray

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.

Original languageEnglish (US)
Pages (from-to)2577-2581
Number of pages5
JournalLife Sciences
Volume34
Issue number26
DOIs
StatePublished - Jun 25 1984

Fingerprint

Motilin
Urinary Bladder
Naloxone
Mammals
Urination
Morphine
Reflex
Brain
Peptides
Experiments

ASJC Scopus subject areas

  • Pharmacology

Cite this

Motilin acts within the CNS to inhibit urinary bladder contractions. / Porreca, Frank; Dray, Andre.

In: Life Sciences, Vol. 34, No. 26, 25.06.1984, p. 2577-2581.

Research output: Contribution to journalArticle

Porreca, Frank ; Dray, Andre. / Motilin acts within the CNS to inhibit urinary bladder contractions. In: Life Sciences. 1984 ; Vol. 34, No. 26. pp. 2577-2581.
@article{d18c76d99dbc4850b11cd89fcb2538da,
title = "Motilin acts within the CNS to inhibit urinary bladder contractions",
abstract = "Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.",
author = "Frank Porreca and Andre Dray",
year = "1984",
month = "6",
day = "25",
doi = "10.1016/0024-3205(84)90043-2",
language = "English (US)",
volume = "34",
pages = "2577--2581",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "26",

}

TY - JOUR

T1 - Motilin acts within the CNS to inhibit urinary bladder contractions

AU - Porreca, Frank

AU - Dray, Andre

PY - 1984/6/25

Y1 - 1984/6/25

N2 - Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.

AB - Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.

UR - http://www.scopus.com/inward/record.url?scp=0021237799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021237799&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(84)90043-2

DO - 10.1016/0024-3205(84)90043-2

M3 - Article

C2 - 6547500

AN - SCOPUS:0021237799

VL - 34

SP - 2577

EP - 2581

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 26

ER -