Motilin acts within the CNS to inhibit urinary bladder contractions

Frank Porreca, Andre Dray

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.

Original languageEnglish (US)
Pages (from-to)2577-2581
Number of pages5
JournalLife Sciences
Issue number26
StatePublished - Jun 25 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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