Motility effects of opioid peptides in dog intestine

Thomas F. Burks, Lane D. Hirning, James J. Galligan, Thomas P. Davis

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Six opioid peptides, like morphine, were found to produce dose-dependent contractions of dog isolated intestine when administered as intraarterial boluses. The increases in incidence and amplitude of intestinal contractions were antagonized by naloxone. The rank order of potency of the opioid agonists tested was D-Ala2-met-enkephalinamide > D-Ala2-leu-enkephalinamide > met-enkephalin > β-endorphin 1-31 > morphine ≥ morphiceptin > dynorphin 1-13. The contractions induced by two opioid agonists displayed differential sensitivity to blockade by tetrodotoxin (TTX). Met-enkephalin was barely affected by concentrations of TTX that markedly reduced responses to morphiceptin. Some portion of the motility effect of met-enkephalin may be exerted directly on intestinal smooth muscle.

Original languageEnglish (US)
Pages (from-to)2237-2240
Number of pages4
JournalLife Sciences
Volume31
Issue number20-21
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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