MRI detects therapeutic effects in weanling Niemann-Pick type C mice

Silvia Lope-Piedrafita, John W. Totenhagen, Chad M. Hicks, Robert P. Erickson, Theodore P. Trouard, Theodore P. Trouard

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

To noninvasively evaluate the early effects of Niemann-Pick type C (NPC) disease, diffusion tensor imaging (DTI) was carried out in the brains of very young (23-day-old) mice. The diffusion of water in white matter tracts of Npc1-/- mice at this young age was already abnormal, exhibiting decreased anisotropy, as quantified by fractional anisotropy (FA), compared with their wild-type littermates, the controls. Postmortem histological staining revealed myelin de.ciencies in Npc1-/ - mice, consistent with the reduction in FA measured vivo. Beneficial effects of treatment with allopregnanolone and/ or 2 hydroxypropyl-beta-cyclodextrin was also detectable at this age by FA, which correlated with increased myelination as seen by histology. This is the earliest detection of a therapeutic effect in Npc1-/- mice.

Original languageEnglish (US)
Pages (from-to)2802-2807
Number of pages6
JournalJournal of Neuroscience Research
Volume86
Issue number12
DOIs
StatePublished - Dec 8 2008

Keywords

  • Allopregnanolone
  • Beta-cyclodextrin
  • Brain
  • DTI
  • Dysmyelination
  • Mouse
  • Neurodegeneration
  • Neurosteroids

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'MRI detects therapeutic effects in weanling Niemann-Pick type C mice'. Together they form a unique fingerprint.

  • Cite this

    Lope-Piedrafita, S., Totenhagen, J. W., Hicks, C. M., Erickson, R. P., Trouard, T. P., & Trouard, T. P. (2008). MRI detects therapeutic effects in weanling Niemann-Pick type C mice. Journal of Neuroscience Research, 86(12), 2802-2807. https://doi.org/10.1002/jnr.21707