MSP dynamics drives nematode sperm locomotion

Charles William Wolgemuth, Long Miao, Orion Vanderlinde, Tom Roberts, George Oster

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Most eukaryotic cells can crawl over surfaces. In general, this motility requires three sequential actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent in vitro experiments with extracts from spermatozoa from the nematode Ascaris suum suggest that retraction forces are generated by depolymerization of the major sperm protein cytoskeleton. Combining polymer entropy with a simple kinetic model for disassembly we propose a model for disassembly-induced retraction that fits the in vitro experimental data. This model explains the mechanism by which disassembly of the cytoskeleton generates the force necessary to pull the cell body forward and suggests further experiments that can test the validity of the models.

Original languageEnglish (US)
Pages (from-to)2462-2471
Number of pages10
JournalBiophysical Journal
Volume88
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

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Locomotion
Cytoskeleton
Spermatozoa
Ascaris suum
Entropy
Eukaryotic Cells
Polymerization
Polymers
Proteins
In Vitro Techniques
Cell Body

ASJC Scopus subject areas

  • Biophysics

Cite this

Wolgemuth, C. W., Miao, L., Vanderlinde, O., Roberts, T., & Oster, G. (2005). MSP dynamics drives nematode sperm locomotion. Biophysical Journal, 88(4), 2462-2471. https://doi.org/10.1529/biophysj.104.054270

MSP dynamics drives nematode sperm locomotion. / Wolgemuth, Charles William; Miao, Long; Vanderlinde, Orion; Roberts, Tom; Oster, George.

In: Biophysical Journal, Vol. 88, No. 4, 04.2005, p. 2462-2471.

Research output: Contribution to journalArticle

Wolgemuth, CW, Miao, L, Vanderlinde, O, Roberts, T & Oster, G 2005, 'MSP dynamics drives nematode sperm locomotion', Biophysical Journal, vol. 88, no. 4, pp. 2462-2471. https://doi.org/10.1529/biophysj.104.054270
Wolgemuth, Charles William ; Miao, Long ; Vanderlinde, Orion ; Roberts, Tom ; Oster, George. / MSP dynamics drives nematode sperm locomotion. In: Biophysical Journal. 2005 ; Vol. 88, No. 4. pp. 2462-2471.
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