MUC1 can interact with adenomatous polyposis coli in breast cancer

Christine L. Hattrup, Julia Fernandez-Rodriguez, Joyce A. Schroeder, Gunnar C. Hansson, Sandra J. Gendler

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The MUC1 tumor antigen is overexpressed on most breast tumors and metastases. It interacts with signaling proteins such as the ErbB kinases and β-catenin, and is involved in mammary gland oncogenesis and tumor progression. Herein, we report a novel interaction between MUC1 and adenomatous polyposis coli (APC), a tumor suppressor involved in downregulating β-catenin signaling. Initially identified in colorectal cancer, APC is also downregulated in breast tumors and presumably involved in mammary carcinogenesis. MUC1 and APC co-immunoprecipitate from the ZR-75-1 human breast carcinoma cell line and co-localize in mouse mammary glands and tumors. These studies also indicate that the association of MUC1 and APC may be increased by epidermal growth factor stimulation. Intriguingly, the co-immunoprecipitation of MUC1 and APC increases in human breast tumors and metastases as compared to adjacent normal tissues, indicating that this association may play a role in the formation and progression of breast tumors.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume316
Issue number2
DOIs
StatePublished - Apr 2 2004

Keywords

  • APC
  • Breast cancer
  • MUC1
  • Mammary gland

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'MUC1 can interact with adenomatous polyposis coli in breast cancer'. Together they form a unique fingerprint.

  • Cite this