MUC1 can interact with adenomatous polyposis coli in breast cancer

Christine L. Hattrup, Julia Fernandez-Rodriguez, Joyce Schroeder, Gunnar C. Hansson, Sandra J. Gendler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The MUC1 tumor antigen is overexpressed on most breast tumors and metastases. It interacts with signaling proteins such as the ErbB kinases and β-catenin, and is involved in mammary gland oncogenesis and tumor progression. Herein, we report a novel interaction between MUC1 and adenomatous polyposis coli (APC), a tumor suppressor involved in downregulating β-catenin signaling. Initially identified in colorectal cancer, APC is also downregulated in breast tumors and presumably involved in mammary carcinogenesis. MUC1 and APC co-immunoprecipitate from the ZR-75-1 human breast carcinoma cell line and co-localize in mouse mammary glands and tumors. These studies also indicate that the association of MUC1 and APC may be increased by epidermal growth factor stimulation. Intriguingly, the co-immunoprecipitation of MUC1 and APC increases in human breast tumors and metastases as compared to adjacent normal tissues, indicating that this association may play a role in the formation and progression of breast tumors.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume316
Issue number2
DOIs
StatePublished - Apr 2 2004

Fingerprint

Adenomatous Polyposis Coli
Tumors
Breast Neoplasms
Catenins
Human Mammary Glands
Carcinogenesis
Down-Regulation
Neoplasm Metastasis
Neoplasm Antigens
Immunoprecipitation
Epidermal Growth Factor
Colorectal Neoplasms
Breast
Phosphotransferases
Cells
Tissue
Cell Line

Keywords

  • APC
  • Breast cancer
  • Mammary gland
  • MUC1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

MUC1 can interact with adenomatous polyposis coli in breast cancer. / Hattrup, Christine L.; Fernandez-Rodriguez, Julia; Schroeder, Joyce; Hansson, Gunnar C.; Gendler, Sandra J.

In: Biochemical and Biophysical Research Communications, Vol. 316, No. 2, 02.04.2004, p. 364-369.

Research output: Contribution to journalArticle

Hattrup, Christine L. ; Fernandez-Rodriguez, Julia ; Schroeder, Joyce ; Hansson, Gunnar C. ; Gendler, Sandra J. / MUC1 can interact with adenomatous polyposis coli in breast cancer. In: Biochemical and Biophysical Research Communications. 2004 ; Vol. 316, No. 2. pp. 364-369.
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