Multi-Directional Dynamic Model for Traumatic Brain Injury Detection

Kaveh Laksari, Michael Fanton, Lyndia C. Wu, Taylor H. Nguyen, Mehmet Kurt, Chiara Giordano, Eoin Kelly, Eoin O'Keeffe, Eugene Wallace, Colin Doherty, Matthew Campbell, Stephen Tiernan, Gerald Grant, Jesse Ruan, Saeed Barbat, David B. Camarillo

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Given the worldwide adverse impact of traumatic brain injury (TBI) on the human population, its diagnosis and prediction are of utmost importance. Historically, many studies have focused on associating head kinematics to brain injury risk. Recently, there has been a push toward using computationally expensive finite element (FE) models of the brain to create tissue deformation metrics of brain injury. Here, we develop a new brain injury metric, the brain angle metric (BAM), based on the dynamics of a 3 degree-of-freedom lumped parameter brain model. The brain model is built based on the measured natural frequencies of an FE brain model simulated with live human impact data. We show that it can be used to rapidly estimate peak brain strains experienced during head rotational accelerations that cause mild TBI. In our data set, the simplified model correlates with peak principal FE strain (R2 = 0.82). Further, coronal and axial brain model displacement correlated with fiber-oriented peak strain in the corpus callosum (R2 = 0.77). Our proposed injury metric BAM uses the maximum angle predicted by our brain model and is compared against a number of existing rotational and translational kinematic injury metrics on a data set of head kinematics from 27 clinically diagnosed injuries and 887 non-injuries. We found that BAM performed comparably to peak angular acceleration, translational acceleration, and angular velocity in classifying injury and non-injury events. Metrics that separated time traces into their directional components had improved model deviance compare with those that combined components into a single time trace magnitude. Our brain model can be used in future work to rapidly approximate the peak strain resulting from mild to moderate head impacts and to quickly assess brain injury risk.

Original languageEnglish (US)
Pages (from-to)982-993
Number of pages12
JournalJournal of Neurotrauma
Volume37
Issue number7
DOIs
StatePublished - Apr 1 2020

Keywords

  • brain injury
  • concussion
  • injury criterion
  • injury prediction

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Laksari, K., Fanton, M., Wu, L. C., Nguyen, T. H., Kurt, M., Giordano, C., Kelly, E., O'Keeffe, E., Wallace, E., Doherty, C., Campbell, M., Tiernan, S., Grant, G., Ruan, J., Barbat, S., & Camarillo, D. B. (2020). Multi-Directional Dynamic Model for Traumatic Brain Injury Detection. Journal of Neurotrauma, 37(7), 982-993. https://doi.org/10.1089/neu.2018.6340