Multi-modality imaging of a murine mammary window chamber for breast cancer research

Rachel Schafer, Hui Min Leung, Arthur F Gmitro

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Window chamber models have been developed and utilized as a means to study the complex microenvironment in which cancers develop, proliferate, and metastasize in small animals. Here we utilize rapid prototyping printer technology to construct a new plastic orthotopic mammary window chamber that is compatible with magnetic resonance imaging, nuclear imaging, and optical imaging. Optical imaging allows for high-resolution cellular and molecular level analysis of tissues; magnetic resonance imaging provides quantitative measures of tumor size, perfusion, diffusion, fat/water content relaxation parameters; and a nuclear imaging technique, called the Beta Imager, supports functional and metabolic imaging. Our demonstration of the multiple imaging capabilities of this model suggests that it can be used as a powerful platform for studying basic cancer biology and developing new cancer therapies.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalBioTechniques
Volume57
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Breast
Breast Neoplasms
Imaging techniques
Optical Imaging
Research
Neoplasms
Magnetic Resonance Imaging
Magnetic resonance
Plastics
Perfusion
Fats
Technology
Water
Rapid prototyping
Image sensors
Water content
Tumors
Animals
Demonstrations
Tissue

Keywords

  • Cancer
  • Imaging
  • Magnetic resonance
  • Nuclear
  • Optical
  • Window chamber

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biotechnology

Cite this

Multi-modality imaging of a murine mammary window chamber for breast cancer research. / Schafer, Rachel; Leung, Hui Min; Gmitro, Arthur F.

In: BioTechniques, Vol. 57, No. 1, 2014, p. 45-50.

Research output: Contribution to journalArticle

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