Multi-modality imaging of a murine mammary window chamber for breast cancer research

Rachel Schafer, Hui Min Leung, Arthur F. Gmitro

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Window chamber models have been developed and utilized as a means to study the complex microenvironment in which cancers develop, proliferate, and metastasize in small animals. Here we utilize rapid prototyping printer technology to construct a new plastic orthotopic mammary window chamber that is compatible with magnetic resonance imaging, nuclear imaging, and optical imaging. Optical imaging allows for high-resolution cellular and molecular level analysis of tissues; magnetic resonance imaging provides quantitative measures of tumor size, perfusion, diffusion, fat/water content relaxation parameters; and a nuclear imaging technique, called the Beta Imager, supports functional and metabolic imaging. Our demonstration of the multiple imaging capabilities of this model suggests that it can be used as a powerful platform for studying basic cancer biology and developing new cancer therapies.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalBioTechniques
Volume57
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Cancer
  • Imaging
  • Magnetic resonance
  • Nuclear
  • Optical
  • Window chamber

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology(all)

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