Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model

Jennifer M. Watson, Photini Faith Rice, Samuel L. Marion, David L. Bentley, Molly A. Brewer, Urs Utzinger, Patricia B Hoyer, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7890
DOIs
StatePublished - 2011
EventAdvanced Biomedical and Clinical Diagnostic Systems IX - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems IX
CountryUnited States
CitySan Francisco, CA
Period1/23/111/25/11

Fingerprint

9,10-Dimethyl-1,2-benzanthracene
Optical Imaging
Optical tomography
Ovarian Neoplasms
mice
Microscopic examination
cancer
Imaging techniques
Anthracene
Optical Coherence Tomography
ovaries
Microscopy
Ovary
Screening
tomography
Microstructure
microscopy
Neoplasms
anthracene
screening

Keywords

  • DMBA
  • fluorescence microscopy
  • multi photon microscopy
  • optical coherence tomography
  • optical imaging
  • ovarian cancer
  • post-menopausal mouse model
  • second harmonic generation
  • VCD

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Watson, J. M., Rice, P. F., Marion, S. L., Bentley, D. L., Brewer, M. A., Utzinger, U., ... Barton, J. K. (2011). Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7890). [78900W] https://doi.org/10.1117/12.875577

Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. / Watson, Jennifer M.; Rice, Photini Faith; Marion, Samuel L.; Bentley, David L.; Brewer, Molly A.; Utzinger, Urs; Hoyer, Patricia B; Barton, Jennifer K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7890 2011. 78900W.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Watson, JM, Rice, PF, Marion, SL, Bentley, DL, Brewer, MA, Utzinger, U, Hoyer, PB & Barton, JK 2011, Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7890, 78900W, Advanced Biomedical and Clinical Diagnostic Systems IX, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.875577
Watson JM, Rice PF, Marion SL, Bentley DL, Brewer MA, Utzinger U et al. Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7890. 2011. 78900W https://doi.org/10.1117/12.875577
Watson, Jennifer M. ; Rice, Photini Faith ; Marion, Samuel L. ; Bentley, David L. ; Brewer, Molly A. ; Utzinger, Urs ; Hoyer, Patricia B ; Barton, Jennifer K. / Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7890 2011.
@inproceedings{dbaf055368f642a783625c6bf03a0643,
title = "Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model",
abstract = "Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.",
keywords = "DMBA, fluorescence microscopy, multi photon microscopy, optical coherence tomography, optical imaging, ovarian cancer, post-menopausal mouse model, second harmonic generation, VCD",
author = "Watson, {Jennifer M.} and Rice, {Photini Faith} and Marion, {Samuel L.} and Bentley, {David L.} and Brewer, {Molly A.} and Urs Utzinger and Hoyer, {Patricia B} and Barton, {Jennifer K}",
year = "2011",
doi = "10.1117/12.875577",
language = "English (US)",
isbn = "9780819484277",
volume = "7890",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model

AU - Watson, Jennifer M.

AU - Rice, Photini Faith

AU - Marion, Samuel L.

AU - Bentley, David L.

AU - Brewer, Molly A.

AU - Utzinger, Urs

AU - Hoyer, Patricia B

AU - Barton, Jennifer K

PY - 2011

Y1 - 2011

N2 - Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.

AB - Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.

KW - DMBA

KW - fluorescence microscopy

KW - multi photon microscopy

KW - optical coherence tomography

KW - optical imaging

KW - ovarian cancer

KW - post-menopausal mouse model

KW - second harmonic generation

KW - VCD

UR - http://www.scopus.com/inward/record.url?scp=79955391500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955391500&partnerID=8YFLogxK

U2 - 10.1117/12.875577

DO - 10.1117/12.875577

M3 - Conference contribution

AN - SCOPUS:79955391500

SN - 9780819484277

VL - 7890

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -