Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model

Jennifer M. Watson, Photini Faith Rice, Samuel L. Marion, David L. Bentley, Molly A. Brewer, Urs Utzinger, Patricia B. Hoyer, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems IX
DOIs
StatePublished - May 2 2011
EventAdvanced Biomedical and Clinical Diagnostic Systems IX - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7890
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems IX
CountryUnited States
CitySan Francisco, CA
Period1/23/111/25/11

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Keywords

  • DMBA
  • VCD
  • fluorescence microscopy
  • multi photon microscopy
  • optical coherence tomography
  • optical imaging
  • ovarian cancer
  • post-menopausal mouse model
  • second harmonic generation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Watson, J. M., Rice, P. F., Marion, S. L., Bentley, D. L., Brewer, M. A., Utzinger, U., Hoyer, P. B., & Barton, J. K. (2011). Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model. In Advanced Biomedical and Clinical Diagnostic Systems IX [78900W] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7890). https://doi.org/10.1117/12.875577