Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry

Arthur Lompado, Matthew H. Smith, Lloyd W. Hillman, Kurt R Denninghoff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Abstract

Scanning laser microscopy is a widely used technique in ophthalmoscopy for providing high-resolution real time images of the retina. We describe a scanning laser ophthalmoscope that acquires retinal images at four wavelengths for the purpose of measuring the oxygen saturation of blood in retinal arteries and veins. Images at all four wavelengths are obtained across a single video frame using a temporal interlacing technique. An extraction procedure then permits analysis of four monochromatic images. A technique for calculating oxygen saturation from a multi-spectral image set is presented, along with preliminary measurements. The choice of wavelengths dramatically affects the oxygen saturation calculation accuracy and we present an optimized wavelength set and the calculated oxygen saturation results. The potential applications for this technology range from the diagnosis of various ophthalmic diseases to the detection of blood loss in trauma victims.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages67-73
Number of pages7
Volume3920
StatePublished - 2000
Externally publishedYes
EventSpectral Imaging: Instrumentation, Applications, and Analysis - San Jose, CA, USA
Duration: Jan 25 2000Jan 25 2000

Other

OtherSpectral Imaging: Instrumentation, Applications, and Analysis
CitySan Jose, CA, USA
Period1/25/001/25/00

Fingerprint

oximetry
vessels
Scanning
saturation
Wavelength
Oxygen
scanning
Lasers
oxygen
wavelengths
blood
lasers
Blood
retinal images
laser microscopy
retina
arteries
veins
Microscopic examination
high resolution

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lompado, A., Smith, M. H., Hillman, L. W., & Denninghoff, K. R. (2000). Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3920, pp. 67-73). Society of Photo-Optical Instrumentation Engineers.

Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry. / Lompado, Arthur; Smith, Matthew H.; Hillman, Lloyd W.; Denninghoff, Kurt R.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3920 Society of Photo-Optical Instrumentation Engineers, 2000. p. 67-73.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lompado, A, Smith, MH, Hillman, LW & Denninghoff, KR 2000, Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3920, Society of Photo-Optical Instrumentation Engineers, pp. 67-73, Spectral Imaging: Instrumentation, Applications, and Analysis, San Jose, CA, USA, 1/25/00.
Lompado A, Smith MH, Hillman LW, Denninghoff KR. Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3920. Society of Photo-Optical Instrumentation Engineers. 2000. p. 67-73
Lompado, Arthur ; Smith, Matthew H. ; Hillman, Lloyd W. ; Denninghoff, Kurt R. / Multi-spectral confocal scanning laser ophthalmoscope for retinal vessel oximetry. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3920 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 67-73
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