Multicenter, randomized study comparing efficacy and safety of oral levofloxacin and cefaclor in treatment of acute bacterial exacerbations of chronic bronchitis

Michael P. Habib, Layne O. Gentry, Guillermo Rodriguez-Gomez, William Morowitz, Elaine Polak, Jena K. Rae, Nancy S. Morgan, R. Rex Williams

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

This prospective, multicenter randomized trial compared the safety and efficacy of 5-7 of therapy with oral levofloxacin (500 mg qd) with 7-10 days of therapy with cefaclor (250 mg tid) in the treatment of patients with acute bacterial exacerbations of chronic bronchitis (ABECB). One hundred ninety- two patients were evaluable of microbiologic efficacy. The overall bacteriologic eradication rates by pathogen were 94% and 87% for levoflaxacin and cefaclor, respectively. Levofloxacin eradicated 100% of Haemophilus influenzae, 95% of Moraxella catarrhalis, and 90% of Streptococcus pneumoniae organisms vs. 71%, 100%, and 86%, respectively, for cefaclor. Clinical success was observed in 92% of the patients in both groups. Drug-related adverse events were reported in 7% and 5% of patients, respectively, with gastrointestinal adverse events being the most common. These results indicate that once a day dosing of levofloxacin (500 mgg) is as effective and well tolerated as three-times-per-day dosing of cefaclor (250 mgg) in the treatment of patients with ABECB.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalInfectious Diseases in Clinical Practice
Volume7
Issue number2
DOIs
StatePublished - Feb 1998

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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