Multidrug and Toxin Extrusion Proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The multidrug and toxin extrusion (MATE) family of transporters plays a central role in clearing the body of cationic, xenobiotic compounds. Expressed principally in the kidney and liver, they mediate the active step in renal and hepatic secretion of a wide array of clinically important drugs. This chapter provides an overview of the cellular and organ level physiology of organic cation (OC) secretion, thereby establishing the "physiological fingerprint" of the process currently believed to be mediated by MATE family members. It discusses characteristics of MATE-mediated transport, including sites of expression, mechanism of action, and selectivity. The molecular characteristics of MATE proteins are then described, including issues pertaining to their structure, genetic diversity, and regulation of expression. The chapter explains the influence of MATE proteins on renal drug clearance.

Original languageEnglish (US)
Title of host publicationDrug Transporters
Subtitle of host publicationMolecular Characterization and Role in Drug Disposition: Second Edition
PublisherWiley-Blackwell
Pages223-243
Number of pages21
Volume9781118489932
ISBN (Electronic)9781118705308
ISBN (Print)9781118489932
DOIs
StatePublished - Sep 2 2014

Keywords

  • Molecular characteristics
  • Multidrug and toxin extrusion (MATE)
  • Organic cation (OC) secretion
  • Renal drug clearance
  • Subcellular distribution

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wright, S. H. (2014). Multidrug and Toxin Extrusion Proteins. In Drug Transporters: Molecular Characterization and Role in Drug Disposition: Second Edition (Vol. 9781118489932, pp. 223-243). Wiley-Blackwell. https://doi.org/10.1002/9781118705308.ch12