Multifaceted roles of TAK1 signaling in cancer

Himadri Mukhopadhyay, Nam Y. Lee

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Context-specific signaling is a prevalent theme in cancer biology wherein individual molecules and pathways can have multiple or even opposite effects depending on the tumor type. TAK1 represents a particularly notable example of such signaling diversity in cancer progression. Originally discovered as a TGF-β-activated kinase, over the years it has been shown to respond to numerous other stimuli to phosphorylate a wide range of downstream targets and elicit distinct cellular responses across cell and tissue types. Here we present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers.

Original languageEnglish (US)
Pages (from-to)1402-1413
Number of pages12
JournalOncogene
Volume39
Issue number7
DOIs
StatePublished - Feb 13 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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