Multiple actions of systemic artemin in experimental neuropathy

Luis R. Gardell, Ruizhong Wang, Chris Ehrenfels, Michael H. Ossipov, Anthony J. Rossomando, Stephan Miller, Carolyn Buckley, Amber K. Cai, Albert Tse, Susan F. Foley, BangJian Gong, Lee Walus, Paul Carmillo, Dane Worley, Carol Huang, Thomas Engber, Blake Pepinsky, Richard L. Cate, Todd W Vanderah, Josephine Lai & 2 others Dinah W Y Sah, Frank Porreca

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

The clinical management of neuropathic pain is particularly challenging. Current therapies for neuropathic pain modulate nerve impulse propagation or synaptic transmission; these therapies are of limited benefit and have undesirable side effects. Injuries to peripheral nerves result in a host of pathophysiological changes associated with the sustained expression of abnormal pain. Here we show that systemic, intermittent administration of artemin produces dose- and time-related reversal of nerve injury-induced pain behavior, together with partial to complete normalization of multiple morphological and neurochemical features of the injury state. These effects of artemin were sustained for at least 28 days. Higher doses of artemin than those completely reversing experimental neuropathic pain did not elicit sensory or motor abnormalities. Our results indicate that the behavioral symptoms of neuropathic pain states can be treated successfully, and that partial to complete reversal of associated morphological and neurochemical changes is achievable with artemin.

Original languageEnglish (US)
Pages (from-to)1383-1389
Number of pages7
JournalNature Medicine
Volume9
Issue number11
DOIs
StatePublished - Nov 2003

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Neuralgia
Pain
Peripheral Nerve Injuries
Behavioral Symptoms
Wounds and Injuries
Synaptic Transmission
Action Potentials
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gardell, L. R., Wang, R., Ehrenfels, C., Ossipov, M. H., Rossomando, A. J., Miller, S., ... Porreca, F. (2003). Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine, 9(11), 1383-1389. https://doi.org/10.1038/nm944

Multiple actions of systemic artemin in experimental neuropathy. / Gardell, Luis R.; Wang, Ruizhong; Ehrenfels, Chris; Ossipov, Michael H.; Rossomando, Anthony J.; Miller, Stephan; Buckley, Carolyn; Cai, Amber K.; Tse, Albert; Foley, Susan F.; Gong, BangJian; Walus, Lee; Carmillo, Paul; Worley, Dane; Huang, Carol; Engber, Thomas; Pepinsky, Blake; Cate, Richard L.; Vanderah, Todd W; Lai, Josephine; Sah, Dinah W Y; Porreca, Frank.

In: Nature Medicine, Vol. 9, No. 11, 11.2003, p. 1383-1389.

Research output: Contribution to journalArticle

Gardell, LR, Wang, R, Ehrenfels, C, Ossipov, MH, Rossomando, AJ, Miller, S, Buckley, C, Cai, AK, Tse, A, Foley, SF, Gong, B, Walus, L, Carmillo, P, Worley, D, Huang, C, Engber, T, Pepinsky, B, Cate, RL, Vanderah, TW, Lai, J, Sah, DWY & Porreca, F 2003, 'Multiple actions of systemic artemin in experimental neuropathy', Nature Medicine, vol. 9, no. 11, pp. 1383-1389. https://doi.org/10.1038/nm944
Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 2003 Nov;9(11):1383-1389. https://doi.org/10.1038/nm944
Gardell, Luis R. ; Wang, Ruizhong ; Ehrenfels, Chris ; Ossipov, Michael H. ; Rossomando, Anthony J. ; Miller, Stephan ; Buckley, Carolyn ; Cai, Amber K. ; Tse, Albert ; Foley, Susan F. ; Gong, BangJian ; Walus, Lee ; Carmillo, Paul ; Worley, Dane ; Huang, Carol ; Engber, Thomas ; Pepinsky, Blake ; Cate, Richard L. ; Vanderah, Todd W ; Lai, Josephine ; Sah, Dinah W Y ; Porreca, Frank. / Multiple actions of systemic artemin in experimental neuropathy. In: Nature Medicine. 2003 ; Vol. 9, No. 11. pp. 1383-1389.
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