Multiple actions of systemic artemin in experimental neuropathy

Luis R. Gardell, Ruizhong Wang, Chris Ehrenfels, Michael H. Ossipov, Anthony J. Rossomando, Stephan Miller, Carolyn Buckley, Amber K. Cai, Albert Tse, Susan F. Foley, Bang Jian Gong, Lee Walus, Paul Carmillo, Dane Worley, Carol Huang, Thomas Engber, Blake Pepinsky, Richard L. Cate, Todd W. Vanderah, Josephine LaiDinah W.Y. Sah, Frank Porreca

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

The clinical management of neuropathic pain is particularly challenging. Current therapies for neuropathic pain modulate nerve impulse propagation or synaptic transmission; these therapies are of limited benefit and have undesirable side effects. Injuries to peripheral nerves result in a host of pathophysiological changes associated with the sustained expression of abnormal pain. Here we show that systemic, intermittent administration of artemin produces dose- and time-related reversal of nerve injury-induced pain behavior, together with partial to complete normalization of multiple morphological and neurochemical features of the injury state. These effects of artemin were sustained for at least 28 days. Higher doses of artemin than those completely reversing experimental neuropathic pain did not elicit sensory or motor abnormalities. Our results indicate that the behavioral symptoms of neuropathic pain states can be treated successfully, and that partial to complete reversal of associated morphological and neurochemical changes is achievable with artemin.

Original languageEnglish (US)
Pages (from-to)1383-1389
Number of pages7
JournalNature Medicine
Volume9
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Gardell, L. R., Wang, R., Ehrenfels, C., Ossipov, M. H., Rossomando, A. J., Miller, S., Buckley, C., Cai, A. K., Tse, A., Foley, S. F., Gong, B. J., Walus, L., Carmillo, P., Worley, D., Huang, C., Engber, T., Pepinsky, B., Cate, R. L., Vanderah, T. W., ... Porreca, F. (2003). Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine, 9(11), 1383-1389. https://doi.org/10.1038/nm944