Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma

Mikhail Kondrashov, Samuel P.S. Svensson, Peter Ström, Andreas Westermark, Hanna Jacobson-Ingemyr, Akihiro Takano, Lenke Tari, Miklós Tóth, Minying Cai, Victor J. Hruby, Magnus Schou

Research output: Contribution to journalArticlepeer-review

Abstract

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

Original languageEnglish (US)
JournalBioconjugate Chemistry
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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